3-氨基-4-硝基三氟甲苯合成路线 (共 19 条)
反应条件
methoxylamine hydrochloride; potassium tert-butylate; copper(l) chloride in N,N-dimethyl-formamide T=20°C; Substitution; Amination;
参考文献
Seko, Shinzo; Miyake, Kunihito; Kavvamura, Norio
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 11 p. 1437 - 1444
反应条件
potassium carbonate in ethanol; water T=50°C; 3 h;
参考文献
Navarrete-Vazquez, Gabriel; Rojano-Vilchis, Maria De Monserrat; Yepez-Mulia, Lilian; Melendez, Victor; Gerena, Lucia; Hernandez-Campos, Alicia; Castillo, Rafael; Hernandez-Luis, Francisco
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 135 - 141
反应条件
1: 33 percent / potassium nitrate / 0 - 25 °C 2: 96 percent / potassium carbonate / ethanol; H2O / 3 h / 50 °C View Scheme
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US5162318 A1, 1992 ;
反应条件
nitric acid T=-10°C; und Erwaermen einer aethanol.Loesung des Reaktionsprodukts (nach Abtrennung von Essigsaeure-<2-nitro-3-trifluormethyl-anilid>) mit wss.Salzsaeure;
参考文献
Pouterman; Girardet
Helvetica Chimica Acta, 1947 , vol. 30, p. 107,110
反应条件
sulfuric acid; nitric acid
参考文献
Rouche
Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1927 , vol. <5> 13, p. 349
Chem. Zentralbl., 1927 , vol. 98, # II p. 1817
参考文献
Rouche
Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1927 , vol. <5> 13, p. 349
Chem. Zentralbl., 1927 , vol. 98, # II p. 1817
反应条件
1: NaNO2; aqueous H2SO4 / anschliessendes Erhitzen mit wss. CuSO4 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Belcher et al.
Journal of the Chemical Society, 1954 , p. 3846,3849
反应条件
methanol; palladium on activated charcoal Hydrogenation;
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
sulfuric acid; acetic acid; sodium nitrite Reagens 4: wss. Hypophosphorigsaeure;
参考文献
Rouche
Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1927 , vol. <5> 13, p. 349
Chem. Zentralbl., 1927 , vol. 98, # II p. 1817
参考文献
Belcher et al.
Journal of the Chemical Society, 1954 , p. 3846,3849