2-溴-4-(三氟甲基)苯甲醚合成路线 （共 7 条）
反应条件
bromine; sodium acetate; acetic acid T=20°C; 23 h;
参考文献
Romines, Karen R.; Freeman, George A.; Schaller, Lee T.; Cowan, Jill R.; Gonzales, Steve S.; Tidwell, Jeffrey H.; Andrews III, Clarence W.; Stammers, David K.; Hazen, Richard J.; Ferris, Robert G.; Short, Steven A.; Chan, Joseph H.; Boone, Lawrence R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 727 - 739
反应条件
1: potassium carbonate / acetone / 24 h / Heating 2: 2.77 g / bromine; sodium acetate / acetic acid / 24 h / 20 °C View Scheme
参考文献
Romines, Karen R.; Freeman, George A.; Schaller, Lee T.; Cowan, Jill R.; Gonzales, Steve S.; Tidwell, Jeffrey H.; Andrews III, Clarence W.; Stammers, David K.; Hazen, Richard J.; Ferris, Robert G.; Short, Steven A.; Chan, Joseph H.; Boone, Lawrence R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 727 - 739
反应条件
hydrogen bromide; sodium nitrite anschliessendes Erhitzen mit CuBr;
参考文献
Benkeser; Buting
Journal of the American Chemical Society, 1952 , vol. 74, p. 3011,3012
反应条件
ammonia; sodium amide
参考文献
Benkeser; Buting
Journal of the American Chemical Society, 1952 , vol. 74, p. 3011,3012
反应条件
1: 2-bromo-1-methoxy-4-(trifluoromethyl)benzene; isopropylmagnesium chloride With lithium chloride in tetrahydrofuran; diethyl ether T=20°C; 15 h; 2: carbon dioxide in tetrahydrofuran; diethyl ether T=-78 - 20°C; 3: With hydrogenchloride; potassium carbonate more than 3 stages;
参考文献
Parmee, Emma R.; Xiong, Yusheng; Guo, Jian; Brockunier, Linda
Patent: US2007/88070 A1, 2007 ;
Location in patent: Page/Page column 17 ;
US 20070088070 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With triisopropyl borate 3: With hydrogenchloride in water; ethyl acetate
参考文献
Mathieu, Veronique; Van Den Berge, Emilie; Ceusters, Justine; Konopka, Tomasz; Cops, Antonin; Bruyere, Celine; Pirker, Christine; Berger, Walter; Trieu-Van, Tran; Serteyn, Didier; Kiss, Robert; Robiette, Raphael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6626 - 6637
反应条件
1: 2-bromo-1-methoxy-4-(trifluoromethyl)benzene; isopropylmagnesium chloride With lithium chloride in tetrahydrofuran; diethyl ether T=20°C; 15 h; 2: carbon dioxide in tetrahydrofuran; diethyl ether T=-78 - 20°C; 3: With hydrogenchloride; potassium carbonate more than 3 stages;
参考文献
Parmee, Emma R.; Xiong, Yusheng; Guo, Jian; Brockunier, Linda
Patent: US2007/88070 A1, 2007 ;
Location in patent: Page/Page column 17 ;
US 20070088070 A1
