(S)-1,4-苯并二噁烷-2-羧基哌嗪合成路线 （共 8 条）
反应条件
trifluoroacetic acid in dichloromethane
T=0°C; 1 h;
参考文献
Rouf, Abdul; Aga, Mushtaq A.; Kumar, Brijesh; Taneja, Subhash Chandra
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6420 - 6422
反应条件
hydrogenchloride in methanol; water
T=30 - 35°C; 4.5 h;
参考文献
Fang; Grover, Paul; Han, Zhengxu; McConville, Fran X.; Rossi, Richard F.; Olsson, Damase J.; Kessler, Donald W.; Wald, Stephen A.; Senanayake, Chris H.
Tetrahedron Asymmetry, 2001 , vol. 12, # 15 p. 2169 - 2174
反应条件
1: SOCl2 / CDCl3 / 1.5 h / 84 °C
2: 1.86 kg / conc. HCl / H2O; methanol / 4.5 h / 30 - 35 °C
View Scheme
参考文献
Fang; Grover, Paul; Han, Zhengxu; McConville, Fran X.; Rossi, Richard F.; Olsson, Damase J.; Kessler, Donald W.; Wald, Stephen A.; Senanayake, Chris H.
Tetrahedron Asymmetry, 2001 , vol. 12, # 15 p. 2169 - 2174
反应条件
1: 24 percent / esterase from Serracia marcescens; aq. NaHCO3; aq. NaOH / toluene / 19.5 h / 25 °C / pH 8.5 - 9.0
2: SOCl2 / CDCl3 / 1.5 h / 84 °C
3: 1.86 kg / conc. HCl / H2O; methanol / 4.5 h / 30 - 35 °C
View Scheme
参考文献
Fang; Grover, Paul; Han, Zhengxu; McConville, Fran X.; Rossi, Richard F.; Olsson, Damase J.; Kessler, Donald W.; Wald, Stephen A.; Senanayake, Chris H.
Tetrahedron Asymmetry, 2001 , vol. 12, # 15 p. 2169 - 2174
反应条件
1: 92 percent / potassium carbonate / acetone / 5.5 h / Heating
2: 24 percent / esterase from Serracia marcescens; aq. NaHCO3; aq. NaOH / toluene / 19.5 h / 25 °C / pH 8.5 - 9.0
3: SOCl2 / CDCl3 / 1.5 h / 84 °C
4: 1.86 kg / conc. HCl / H2O; methanol / 4.5 h / 30 - 35 °C
View Scheme
参考文献
Fang; Grover, Paul; Han, Zhengxu; McConville, Fran X.; Rossi, Richard F.; Olsson, Damase J.; Kessler, Donald W.; Wald, Stephen A.; Senanayake, Chris H.
Tetrahedron Asymmetry, 2001 , vol. 12, # 15 p. 2169 - 2174
反应条件
1: whole cells of Arthrobacter sp. ABL MTCC No. 5125 lipase / aq. phosphate buffer; di-isopropyl ether / 2 h / 25 °C / pH 7.1
2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 0.17 h / 0 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
View Scheme
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 8 h
2: potassium hydroxide; potassium permanganate / water; acetone / 0.5 h / 0 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran; dichloromethane / 0 °C
4: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
View Scheme
参考文献
Rouf, Abdul; Aga, Mushtaq A.; Kumar, Brijesh; Taneja, Subhash Chandra
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6420 - 6422
反应条件
1: potassium hydroxide; potassium permanganate / water; acetone / 0.5 h / 0 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran; dichloromethane / 0 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
View Scheme
参考文献
Rouf, Abdul; Aga, Mushtaq A.; Kumar, Brijesh; Taneja, Subhash Chandra
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6420 - 6422
