1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate in toluene T=50°C; 23 h;

1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in water; acetic acid 1 h; Heating;

1.1: methanol / 24 h / 60 °C 2.1: tert.-butyl lithium / tetrahydrofuran; n-heptane / 1 h / -78 °C / |Inert atmosphere 2.2: 1 h / -78 - 20 °C / |Inert atmosphere 3.1: sodium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 23 h / 50 °C View Scheme

1.1: tert.-butyl lithium / tetrahydrofuran; n-heptane / 1 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 - 20 °C / |Inert atmosphere 2.1: sodium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 23 h / 50 °C View Scheme

1.1: SeO2 / pyridine / 26 h / Heating 2.1: 8.2 g / conc. H2SO4 / 8 h / Heating 3.1: 78 percent / m-CPBA / CHCl3 / 15 h / 20 °C 4.1: Ac2O / 3 h / Heating 4.2: 51 percent / NaOMe / methanol / 0.17 h / 0 °C 5.1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C 6.1: 77 percent / AIBN; NBS / CCl4 / Heating 7.1: 34 percent / hexamethylenetetramine; aq. acetic acid / 1 h / Heating View Scheme

1.1: 78 percent / m-CPBA / CHCl3 / 15 h / 20 °C 2.1: Ac2O / 3 h / Heating 2.2: 51 percent / NaOMe / methanol / 0.17 h / 0 °C 3.1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C 4.1: 77 percent / AIBN; NBS / CCl4 / Heating 5.1: 34 percent / hexamethylenetetramine; aq. acetic acid / 1 h / Heating View Scheme

1.1: Ac2O / 3 h / Heating 1.2: 51 percent / NaOMe / methanol / 0.17 h / 0 °C 2.1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C 3.1: 77 percent / AIBN; NBS / CCl4 / Heating 4.1: 34 percent / hexamethylenetetramine; aq. acetic acid / 1 h / Heating View Scheme

1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C 2: 77 percent / AIBN; NBS / CCl4 / Heating 3: 34 percent / hexamethylenetetramine; aq. acetic acid / 1 h / Heating View Scheme

1: 77 percent / AIBN; NBS / CCl4 / Heating 2: 34 percent / hexamethylenetetramine; aq. acetic acid / 1 h / Heating View Scheme

1.1: 8.2 g / conc. H2SO4 / 8 h / Heating 2.1: 78 percent / m-CPBA / CHCl3 / 15 h / 20 °C 3.1: Ac2O / 3 h / Heating 3.2: 51 percent / NaOMe / methanol / 0.17 h / 0 °C 4.1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C 5.1: 77 percent / AIBN; NBS / CCl4 / Heating 6.1: 34 percent / hexamethylenetetramine; aq. acetic acid / 1 h / Heating View Scheme