3,4-二甲氧基苯乙基溴合成路线 （共 22 条）
反应条件
potassium carbonate; potassium iodide in acetonitrile T=95°C; 4 h;
参考文献
Li, Yan; Wang, Xia; Zhang, Jinming; Deuther-Conrad, Winnie; Xie, Fang; Zhang, Xiaojun; Liu, Jian; Qiao, Jinping; Cui, Mengchao; Steinbach, Joerg; Brust, Peter; Liu, Boli; Jia, Hongmei
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3478 - 3491
参考文献
Hoffmann-La Roche
Patent: DE1109700 , 1959 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; 12 h;
参考文献
Shahane, Saurabh; Louafi, Fadila; Moreau, Julie; Hurvois, Jean-Pierre; Renaud, Jean-Luc; Van De Weghe, Pierre; Roisnel, Thierry
European Journal of Organic Chemistry, 2008 , # 27 p. 4622 - 4631
反应条件
potassium bromide in N-methyl-acetamide
参考文献
G.D. Searle and Co.
Patent: EP267439 A3, 1988 ;
反应条件
triphenylphosphine in dichloromethane
参考文献
The Du Pont Merck Pharmaceutical Company
Patent: US5491152 A1, 1996 ;
反应条件
1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
2: pyridine; phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Kiruthika, Selvarangam E.; Perumal, Paramasivan Thirumalai
Organic Letters, 2014 , vol. 16, # 2 p. 484 - 487
反应条件
(i) LiAlH4, (ii) PBr3; Multistep reaction;
参考文献
Hohenlohe-Oehringen,K.
Monatshefte fuer Chemie, 1962 , vol. 93, p. 586 - 599
反应条件
sodium iodide in acetone
24 h; Reflux;
参考文献
Shahane, Saurabh; Louafi, Fadila; Moreau, Julie; Hurvois, Jean-Pierre; Renaud, Jean-Luc; Van De Weghe, Pierre; Roisnel, Thierry
European Journal of Organic Chemistry, 2008 , # 27 p. 4622 - 4631
反应条件
1: 1.) KOH / 1.) Me2SO, 100-110 deg C, 1 h, 2a.) RT, 2 d, 2b.) 70 deg C, 5 h
2: 81 percent / LiAlH4 / tetrahydrofuran / 48 h / Ambient temperature
3: 72 percent / trifluoroacetic anhydride, trifluoroacetic acid / CH2Cl2 / 48 h / Heating
View Scheme
参考文献
Kohn, Harold; Zeng-Kun Liao
Journal of Organic Chemistry, 1982 , vol. 47, # 14 p. 2787 - 2789
反应条件
1: triethylamine / ethanol
2: 62 percent / 10percent HCl / Heating
View Scheme
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
