7-甲氧基-3-甲基异喹啉合成路线 （共 6 条）
反应条件
boron tribromide in dichloromethane T=20°C; 2.5 h;
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
Location in patent: Page/Page column 66 ;
WO 2012/109108 A1
反应条件
air; copper(l) iodide in isopropyl alcohol
T=20 - 55°C; 54 h;
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
Location in patent: Page/Page column 65-66 ;
WO 2012/109108 A1
反应条件
1.1: sodium sulfate; acetic acid / 1.5 h / 20 °C
1.2: 2.67 h
1.3: pH 7
2.1: trifluoroacetic acid / 55 °C / Inert atmosphere
3.1: air / copper(l) iodide / isopropyl alcohol / 54 h / 20 - 55 °C
View Scheme
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
WO 2012/109108 A1
反应条件
1: trifluoroacetic acid / 55 °C / Inert atmosphere
2: air / copper(l) iodide / isopropyl alcohol / 54 h / 20 - 55 °C
View Scheme
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
WO 2012/109108 A1
反应条件
1: 79 percent / 15percent aq. NH4Cl / diethyl ether
2: 18 percent / ClSO3H / 72 h / Ambient temperature
View Scheme
参考文献
Kido, Kazuko; Watanabe, Yasuo
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 12 p. 4964 - 4966
反应条件
chlorosulfonic acid
72 h; Ambient temperature;
参考文献
Kido, Kazuko; Watanabe, Yasuo
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 12 p. 4964 - 4966
