(1-苄基哌啶-4-基)乙酸乙酯合成路线 （共 20 条）
反应条件
1: Et3N / CH2Cl2 2: NaH / tetrahydrofuran View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1.1: H2 / Pd/C / ethanol / 48 h / 2280 Torr 2.1: aq. ammonium formate / ethanol / 2.5 h / Heating 2.2: 3 h / 100 °C 3.1: 3.5 g / aq. NaOH / 1 h / 20 °C View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 20 h; Heating;
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Doernyei, Gabor; Incze, Maria; Moldvai, Istvan; Szantay, Csaba
Synthetic Communications, 2003 , vol. 33, # 13 p. 2329 - 2338
反应条件
hydrogen; palladium dihydroxide in ethanol
参考文献
Kordik, Cheryl P.; Luo, Chi; Gutherman, Maryann; Vaidya, Anil H.; Rosenthal, Daniel I.; Crooke, Jeffrey J.; McKenney, Sandra L.; Plata-Salaman, Carlos R.; Reitz, Allen B.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 3065 - 3067
反应条件
1: 31 percent / tetramethylguanidine / 336 h / Ambient temperature 2: 25 percent / H2 / Pt2O / ethanol View Scheme
参考文献
Cignarella; Villa; Barlocco
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1357 - 1359
反应条件
sodium chloride; sodium hydrogencarbonate; triethylamine in methanol; anhydrous dichloroethane
参考文献
Eisai Co., Ltd.
Patent: US6518423 B1, 2003 ;
反应条件
1: 91 percent / LAH / tetrahydrofuran / 2 h / Heating
2: 46 percent / p-toluenesulfonic acid / benzene / Heating
View Scheme
参考文献
Dutta; Xu; Reith
Journal of Medicinal Chemistry, 1996 , vol. 39, # 3 p. 749 - 756
反应条件
1: platinum on activated charcoal; hydrogen / 10 h / 20 °C / 15514.9 Torr
2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / |Reflux
3: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
View Scheme
参考文献
Luo, Zonghua; Sheng, Jianfei; Sun, Yang; Lu, Chuanjun; Yan, Jun; Liu, Anqiu; Luo, Hai-Bin; Huang, Ling; Li, Xingshu
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9089 - 9099
反应条件
hydrogen; Lindlar catalyst in methanol
0.833333 h;
参考文献
Ghosh, Arun K.; Krishnan
Tetrahedron Letters, 1998 , vol. 39, # 9 p. 947 - 948
