3,5-双三氟甲基苯甲醛合成路线 （共 36 条）
反应条件
sodium methylate in methanol; ethyl acetate
5 h; Heating;
参考文献
Eriks Ch.; Van Der Goot; Nauta Th.
European Journal of Medicinal Chemistry, 1979 , vol. 14, # 5 p. 411 - 414
反应条件
1: diethyl ether
2: CrO3; aq. H2SO4
3: pyridine / ethanol
4: NaBH4; ZrCl4
View Scheme
参考文献
Bloom, Jonathan D.; Dushin, Russell G.; Curran, Kevin J.; Donahue, Fran; Norton, Emily B.; Terefenko, Eugene; Jones, Thomas R.; Ross, Adma A.; Feld, Boris; Lang, Stanley A.; DiGrandi, Martin J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 13 p. 3401 - 3406
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran
T=0°C; 0.166667 h;
2: 3,5-bis-(trifluoromethyl)-benzaldehyde in tetrahydrofuran
T=0 - 20°C;
3: With diisobutylaluminium hydride in dichloromethane; toluene
T=-78°C;
参考文献
Zhang, Yinan; Benmohamed, Radhia; Zhang, Wei; Kim, Jinho; Edgerly, Christina K.; Zhu, Yaoqiu; Morimoto, Richard I.; Ferrante, Robert J.; Kirsch, Donald R.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 7 p. 584 - 587
反应条件
1.1: NaH / tetrahydrofuran / 0 °C
1.2: tetrahydrofuran / 0 °C
2.1: DIBAL / toluene / -70 °C
View Scheme
参考文献
Sauerberg, Per; Mogensen, John P.; Jeppesen, Lone; Bury, Paul S.; Fleckner, Jan; Olsen, Grith S.; Jeppesen, Claus B.; Wulff, Erik M.; Pihera, Pavel; Havranek, Miroslav; Polivka, Zdenek; Pettersson, Ingrid
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3198 - 3202
反应条件
1: hydroxylamine
2: N-chloro-succinimide / N,N-dimethyl-formamide
View Scheme
参考文献
Gucma, Miroslaw; Golebiewski, W. Marek
Monatshefte fur Chemie, 2010 , vol. 141, # 4 p. 461 - 469
反应条件
1: trimethylsilylazide; scandium tris(trifluoromethanesulfonate) / dichloromethane / 6 h / 20 °C / |Inert atmosphere
2: scandium tris(trifluoromethanesulfonate); triethylsilane / dichloromethane / 24 h / 50 °C / |Inert atmosphere
View Scheme
参考文献
Pramanik, Suman; Ghorai, Prasanta
Organic Letters, 2014 , vol. 16, # 8 p. 2104 - 2107
