2-碘-3-氨基-6-氯吡啶合成路线 （共 4 条）
反应条件
iodine; silver sulphate in ethanol T=20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2009/253736 A1, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 24 h / 65 °C / |Inert atmosphere 2: hydrogenchloride / methanol / 21 h / 75 °C 3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
EP 2548876 A1
反应条件
1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 24 h / 65 °C / |Inert atmosphere 2: hydrogenchloride / methanol; water / 21 h / 75 °C View Scheme
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
EP 2548876 A1
反应条件
1.1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 24 h / 65 °C / |Inert atmosphere 2.1: hydrogenchloride / methanol / 21 h / 75 °C 3.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation 4.1: copper(ll) bromide / acetonitrile / 1 h / 20 °C 4.2: 0.5 h / 20 °C View Scheme
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
EP 2548876 A1
