2-氨基-1,3,4-噻二唑合成路线 （共 44 条）
反应条件
in benzene 48 h; Heating;
参考文献
Chimirri; Grasso; Monforte; et al.
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 11 p. 839 - 851
反应条件
bromine; sodium hydrogencarbonate in methanol T=20°C;
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO)
Patent: WO2009/40552 A2, 2009 ;
Location in patent: Page/Page column 50-51 ;
WO 2009/040552 A2
反应条件
bromine in ethanol; water; acetic acid
参考文献
Pharmacia and Upjohn Company
Patent: US6211376 B1, 2001 ;
反应条件
in 1,4-dioxane 5 h; Reflux;
参考文献
Hamama, Wafaa S.; Gouda, Moustafa A.; Badr, Marwa H.; Zoorob, Hanafi H.
Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3556 - 3565
反应条件
in toluene T=0 - 20°C;
参考文献
Nagao, Yoshimitsu; Iimori, Hitoshi; Nam, Ki Hong; Sano, Shigeki; Shiro, Motoo
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1660 - 1661
参考文献
Ainsworth
Journal of the American Chemical Society, 1956 , vol. 78, p. 1973
参考文献
Ainsworth
Journal of the American Chemical Society, 1956 , vol. 78, p. 1973
参考文献
Coburn,R.A. et al.
Journal of Organic Chemistry, 1973 , vol. 38, p. 3947 - 3949
参考文献
Werber,G. et al.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 1263 - 1265
反应条件
tert.-butylhydroperoxide; trifluoroacetic acid in dichloromethane; water T=23°C; 24 h; regioselective reaction;
参考文献
THE SCRIPPS RESEARCH INSTITUTE; BARAN, Phil, S.; DIXON, Janice, Akemi; BAXTER, Ryan; FUJIWARA, Yuta
Patent: WO2013/82028 A1, 2013 ;
Location in patent: Page/Page column 20; 21; 32 ;
