5alpha-二氢皮质醇21-乙酸酯合成路线 （共 11 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethanol; ethyl acetate T=20°C; 0.666667 h;
参考文献
SAGE THERAPEUTICS, INC.; SALITURO, Francesco, Gerald; ROBICHAUD, Albert, Jean
Patent: WO2013/188792 A2, 2013 ;
Location in patent: Page/Page column 106; 107; 108 ;
反应条件
barium sulfate; palladium on activated charcoal; ethyl acetate Hydrogenation;
参考文献
SAGE THERAPEUTICS, INC.; SALITURO, Francesco, Gerald; ROBICHAUD, Albert, Jean
Patent: WO2013/188792 A2, 2013 ;
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; 5 palladium on charcoal in ethanol 5 h; Reflux; Reagent/catalyst; Overall yield = 80 percent; stereoselective reaction;
参考文献
Ramachary, Dhevalapally B.; Sakthidevi, Rajasekar; Reddy, P. Srinivasa
RSC Advances, 2013 , vol. 3, # 32 p. 13497 - 13506
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal 1.) ethyl acetate, ethanol, 14 h, atmospheric pressure; Yield given. Multistep reaction;
参考文献
Hosoda; Osanai; Fukasawa; Nambara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 1949 - 1952
反应条件
sodium tetrahydroborate aufeinanderfolgende Umsetzung mit Acetanhydrid und mit wss.HCl;
参考文献
Brooks et al.
Journal of the Chemical Society, 1958 , p. 4614,4620
反应条件
1: toluene-4-sulfonic acid-hydrate 2: sodium borate; aqueous methanol 3: aqueous methanol.H2SO4 4: Acetylierung View Scheme
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
3751-02-8[2-(17-羟基-10,13-二甲基-3,11-二氧代-1,2,4,5,6,7,8,9,12,14,15,16-十二氢环戊烯并[a]菲-17-基)-2-氧代乙基]乙酸酯
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反应条件
1: aqueous methanol.KOH 2: toluene-4-sulfonic acid-hydrate 3: sodium borate; aqueous methanol 4: aqueous methanol.H2SO4 5: Acetylierung View Scheme
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
反应条件
1: aqueous methanol.H2SO4 2: Acetylierung View Scheme
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
反应条件
1: sodium borate; aqueous methanol 2: aqueous methanol.H2SO4 3: Acetylierung View Scheme
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
