2-溴-3-(溴甲基)噻吩合成路线 （共 10 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 3 h; Heating;
参考文献
Finch, Harry; Reece, Donald H.; Sharp, John T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 9 p. 1193 - 1204
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in tetrachloromethane 2 h; Heating;
参考文献
Archer, William J.; Cook, Robert; Taylor, Roger
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 813 - 820
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5840917 A1, 1998 ;
反应条件
N-bromosuccinmide in chloroform; acetic acid Ambient temperature;
参考文献
Raju; Okun, Ilya; Stavros, Fiona; Chan, Ming Fai
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 7 p. 933 - 938
反应条件
1: 73 percent / Br2, PPh3, pyridine / CH2Cl2 / 0 °C 2: 82 percent / NBS / acetic acid; CHCl3 / Ambient temperature View Scheme
参考文献
Raju; Okun, Ilya; Stavros, Fiona; Chan, Ming Fai
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 7 p. 933 - 938
反应条件
4-methylmorpholine N-oxide in acetonitrile T=0°C; 2 h; Molecular sieveInert atmosphereSchlenk technique;
参考文献
Levine, David R.; Siegler, Maxime A.; Tovar, John D.
Journal of the American Chemical Society, 2014 , vol. 136, # 19 p. 7132 - 7139
反应条件
silver nitrate in water; acetone
参考文献
Warner-Lambert Company
Patent: US6528510 B1, 2003 ;
反应条件
sodium hydride in tetrahydrofuran T=0°C;
参考文献
Ng, Man-Kit; Yu, Luping
Angewandte Chemie - International Edition, 2002 , vol. 41, # 19 p. 3598 - 3601
参考文献
McCullough, Richard D.; Williams, Shawn P.
Journal of the American Chemical Society, 1993 , vol. 115, # 24 p. 11608 - 11609
反应条件
1: 79 percent / dimethylformamide / room temperature, 90 min, 45 deg C, 90 min 2: 55 percent / N2H4*H2O / methanol / 1 h, room temperature, reflux, 10 min View Scheme
参考文献
Finch, Harry; Reece, Donald H.; Sharp, John T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 9 p. 1193 - 1204
