苄基-((E)-3-苯基-烯丙基)-胺合成路线 （共 35 条）
反应条件
1: With propylamine; O,O'-(R)-(1,1'-dinaphthyl-2,2'-diyl)-N-cyclododecyl-N'-(R,R)-phenylethylphosphoramidite; [Ir(μ-Cl)(1,5-cyclooctadiene)]2 in tetrahydrofuran
T=50°C; 0.333333 h;
2: methyl (2E)-3-phenyl-2-propenyl carbonate; benzylamine in tetrahydrofuran
T=20°C; 3 h; Product distribution / selectivity;
参考文献
YALE UNIVERSITY
Patent: WO2005/111050 A2, 2005 ;
Location in patent: Page/Page column 53; 55-57 ;
反应条件
zinc borohydride; silica gel in ethylene glycol dimethyl ether
1 h;
参考文献
Chandrasekhar; Reddy; Ahmed
Synlett, 2000 , # 11 p. 1655 - 1657
反应条件
bis(η3-allyl-μ-chloropalladium(II)); (S,Rphos,R)-[(BINOL)(Et2N)P][4-Ph-oxazole-deriv.]ferrocene in dichloromethane
T=0°C; 7 h;
参考文献
You; Zhu; Luo; Hou; Dai
Journal of the American Chemical Society, 2001 , vol. 123, # 30 p. 7471 - 7472
反应条件
1: 3-phenyl-3-hydroxypropene With phenoxypolystyrene resin; triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=20°C; Mitsunobu coupling; 12 h;
2: benzylamine With 1,2-bis-(diphenylphosphino)ethane; bis(acetylacetonato) palladium in tetrahydrofuran
Heating;
参考文献
Fisher, Martyn; Brown, Richard C.D
Tetrahedron Letters, 2001 , vol. 42, # 46 p. 8227 - 8230
反应条件
mercaptoacetic acid; triethylamine in dichloromethane
T=20°C; 1 h;
参考文献
Blid, Jan; Brandt, Peter; Somfai, Peter
Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 3043 - 3049
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=110°C; Tsuji-Trost Allylation; 15 h; Inert atmosphere;
参考文献
Vaddula, Buchi Reddy; Saha, Amit; Varma, Rajender S.; Leazer, John
European Journal of Organic Chemistry, 2012 , # 34 p. 6707 - 6709
反应条件
R(a)-2,2'-binaphthyl-bis-((R)-1-phenylethyl)phosphoramidite; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium in ethanol
T=20°C; 16 h; Title compound not separated from byproducts.;
参考文献
Ohmura, Toshimichi; Hartwig, John F.
Journal of the American Chemical Society, 2002 , vol. 124, # 51 p. 15164 - 15165
反应条件
propylamine; 4 A molecular sieve; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium in tetrahydrofuran
T=50°C; 24 h; Title compound not separated from byproducts.;
参考文献
Yamashita, Yasuhiro; Gopalarathnam, Apsara; Hartwig, John F.
Journal of the American Chemical Society, 2007 , vol. 129, # 24 p. 7508 - 7509
反应条件
1: With sodium hydride in N,N-dimethyl-formamide
T=60°C; 16 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=20°C; 1 h; Further stages.;
参考文献
Bower, John F.; Szeto, Peter; Gallagher, Timothy
Organic Letters, 2007 , vol. 9, # 17 p. 3283 - 3286
反应条件
1: N,N-dibenzyl-N-methoxymethylamine With chloro-trimethyl-silane; tin(IV) chloride in 1,2-dichloro-ethane
0.5 h;
2: phenylacetylene in 1,2-dichloro-ethane
T=83°C; 0.75 h;
3: With sodium hydroxide
0.5 h;
参考文献
Rehn, Susanne; Ofial, Armin R.; Mayr, Herbert
Synthesis, 2003 , # 12 p. 1790 - 1796
