1-(3-氯苯基)-1-丙胺合成路线 （共 3 条）
反应条件
ammonium chloride; lithium hexamethyldisilazane in tetrahydrofuran; diethyl ether
T=20°C; 24 h; Heating / reflux;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2005/68460 A1, 2005 ;
Location in patent: Page/Page column 201 ;
WO 2005/068460 A1
反应条件
1: 3-chloro-benzaldehyde With lithium hexamethyldisilazane in tetrahydrofuran
T=0°C; 0.333333 h;
2: ethylmagnesium bromide in tetrahydrofuran; diethyl ether
24 h; Heating / reflux;
参考文献
Schering Corporation and Pharmacopeia, Inc.
Patent: US2004/147559 A1, 2004 ;
Location in patent: Page 121 ;
US 20040147559 A1
反应条件
1: NH2OH*HCl; NaOAc / methanol / 18 h / 20 °C
2: H2; thiophene; NH3 / RaNi / methanol
View Scheme
参考文献
Van Lommen, Guy; Doyon, Julien; Coesemans, Erwin; Boeckx, Staf; Cools, Marina; Buntinx, Mieke; Hermans, Bart; VanWauwe, Jean
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 497 - 500
