1: With water; sodium hydroxide in 1,4-dioxane T=20°C; 1 h; 2: With hydrogenchloride in 1,4-dioxane; water

(i) nBuLi, Et2O, (ii) /BRN= 1900390/; Multistep reaction;

benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-5°C;

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / pH 8.5 2: palladium 10 on activated carbon; hydrogen / methanol / 48 h / 760.05 Torr 3: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12.25 h / -5 - 23 °C / |Inert atmosphere; |Large scale View Scheme

in toluene

in anhydrous xylene