4-氨基-3-硝基三氟甲苯合成路线 （共 50 条）
反应条件
1: 1.) NaNO2, conc. aq. HCl / 1.) H2O, 30 min, 2.) H2O, 1.5 h 2: aq. HCl / Heating 3: 83 percent / FeSO4*7H2O, aq. NH4OH / ethanol / 70 °C View Scheme
参考文献
Wani; Nicholas; Manikumar; Wall
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1774 - 1779
反应条件
1: aqueous H2SO4; NaNO2 / anschliessendes Erhitzen mit CuSO4 2: HNO3; H2O; H2SO4 / 110 °C View Scheme
参考文献
Jagupol'skii; Mospan
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1955 , vol. 21, p. 81,83
Chem.Abstr., 1955 , p. 8866
反应条件
1: aqueous H2SO4; NaNO2 / anschliessendes Erhitzen mit CuSO4 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Pettit; Tatlow
Journal of the Chemical Society, 1954 , p. 3852
反应条件
iodine; silver sulphate in ethanol T=20°C; 36 h;
参考文献
Koradin, Christopher; Dohle, Wolfgang; Rodriguez, Alain L.; Schmid, Bertram; Knochel, Paul
Tetrahedron, 2003 , vol. 59, # 9 p. 1571 - 1587
Title/Abstract Full Text View citing articles Show Details
Dohle, Wolfgang; Staubitz, Anne; Knochel, Paul
Chemistry - A European Journal, 2003 , vol. 9, # 21 p. 5323 - 5331
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; 4 h;
参考文献
Takano, Yasuo; Shiga, Futoshi; Asano, Jun; Hori, Wataru; Fukuchi, Kazunori; Anraku, Tsuyoshi; Uno, Takashi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 776 - 792
反应条件
stannous chloride in ethanol
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
sulfuric acid; sodium nitrite anschliessendes Erhitzen mit CuSO4;
参考文献
Pettit; Tatlow
Journal of the Chemical Society, 1954 , p. 3852
Full Text Show Details
Jagupol'skii; Mospan
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1955 , vol. 21, p. 81,83
Chem.Abstr., 1955 , p. 8866
反应条件
1: 97 percent / H2SO4 / 1 h / 80 °C 2: 98.6 percent / KOH / 1,2-dimethoxy-ethane / 32 - 35 °C 3: 98 percent / H2SO4 / H2O / 0.25 h / 80 - 90 °C 4: H2; Raney Ni / ethanol / 25 °C View Scheme
参考文献
Navarrete-Vazquez, Gabriel; Rojano-Vilchis, Maria De Monserrat; Yepez-Mulia, Lilian; Melendez, Victor; Gerena, Lucia; Hernandez-Campos, Alicia; Castillo, Rafael; Hernandez-Luis, Francisco
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 135 - 141
反应条件
(i) NaNO2, aq. H2SO4, (ii) /BRN= 969212/, NaOAc; Multistep reaction;
参考文献
Forbes,E.J. et al.
Tetrahedron, 1960 , vol. 8, p. 73 - 78
反应条件
palladium in ethanol
参考文献
G. D. Searle and Co.
Patent: US4687775 A1, 1987 ;
