4-氨基-3-三氟甲基苯甲酸合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C;
参考文献
STEIN, Philip; DAINES, Robert; SPROUS, Dennis; O'GRADY, Harold
Patent: WO2010/132615 A1, 2010 ;
Location in patent: Page/Page column 119 ;
WO 2010/132615 A1
反应条件
1: With sodium hydroxide; ethanol; water T=45°C; 2 h; 2: With hydrogenchloride in ethenol Acidic conditions;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/37810 A1, 2004 ;
Location in patent: Page/Page column 144-145 ;
WO 2004/037810 A1
反应条件
sodium hydroxide in ethanol; water 5 h; Heating;
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: aqueous H2SO4 / 190 °C 2: iron-powder; aqueous NH4Cl View Scheme
参考文献
Caldwell; Sayin
Journal of the American Chemical Society, 1951 , vol. 73, p. 5125
反应条件
1: 89 percent / toluene / 5 h / Heating 2: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 3: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 2: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: I2, CaCO3 / methanol; H2O / 24 h / 45 °C 2: 89 percent / toluene / 5 h / Heating 3: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 4: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
sulfuryl dichloride in chloroform 8 h; Heating;
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating 2: SOCl2 / 2 h / Heating View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=0 - 10°C; 0.5 h;
2: With potassium iodide in water
T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/140174 A2, 2007 ;
Location in patent: Page/Page column 42 ;
