3-三氟甲基-4-溴苯甲醚合成路线 （共 5 条）
反应条件
bromine in acetic acid
参考文献
Tietze, Lutz F.; Vock, Carsten A.; Krimmelbein, Ilga K.; Nacke, Linda
Synthesis, 2009 , # 12 art. no. T20108SS, p. 2040 - 2060
反应条件
in N-methyl-acetamide; water
参考文献
Showa Shell Sekiyu Kabushiki Kaisha
Patent: EP423991 A2, 1991 ;
反应条件
bromine; iron in tetrachloromethane T=-60°C; 2 h; Title compound not separated from byproducts;
参考文献
Karl, Johann; Gust, Ronald; Spruss, Thilo; Schneider, Martin R.; Schoenenberg, Helmut; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 72 - 83
反应条件
hydrogenchloride; iodine in tetrahydrofuran
参考文献
Showa Shell Sekiyu Kabushiki Kaisha
Patent: EP423991 A2, 1991 ;
反应条件
1: 3-trifluoromethyl-4-bromo-1-methoxy-benzene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.5 h; Inert atmosphere; 2: 1-piperidinecarboxaldehyde in tetrahydrofuran; pentane T=-78 - 20°C; Inert atmosphere;
参考文献
Tietze, Lutz F.; Vock, Carsten A.; Krimmelbein, Ilga K.; Nacke, Linda
Synthesis, 2009 , # 12 art. no. T20108SS, p. 2040 - 2060
