6-羟甲基吡啶-2-羧酸甲酯合成路线 （共 21 条）
参考文献
Mathes et al.
Chemische Berichte, 1953 , vol. 86, p. 584,587
反应条件
water; sodium hydroxide in methanol T=100°C; 0.166667 h; Microwave irradiationInert atmosphere;
参考文献
Wang, Shuai; Cuesta-Seijo, Jose A.; Lafont, Dominique; Palcic, Monica M.; Vidal, Sebastien
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15346 - 15357
反应条件
manganese(IV) oxide in dichloromethane T=25°C; 96 h;
参考文献
DeGoey, David A.; Flentge, Charles A.; Flosi, William J.; Grampovnik, David J.; Kempf, Dale J.; Klein, Larry L.
Patent: US2005/131017 A1, 2005 ;
Location in patent: Page/Page column 106 ;
反应条件
phosphorus tribromide in chloroform T=20°C; 4 h;
参考文献
Zeng, Xianshun; Coquiere, David; Alenda, Aurelie; Garrier, Eva; Prange, Thierry; Li, Yun; Reinaud, Olivia; Jabin, Ivan
Chemistry - A European Journal, 2006 , vol. 12, # 24 p. 6393 - 6402
反应条件
1: With sodium ethanolate in toluene 5 h; Heating; 2: With sulfuric acid 2 h; Heating; Further stages.;
参考文献
Synthetic Communications, , vol. 37, # 19 p. 3393 - 3402
反应条件
1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 3 h / 20 °C 2: sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / |Reflux View Scheme
参考文献
Dungan, Victoria J.; Poon, Belinda M.-L.; Barrett, Elizabeth S.; Rutledge, Peter J.
Tetrahedron Letters, 2013 , vol. 54, # 10 p. 1236 - 1238
反应条件
thionyl chloride in dichloromethane T=25 - 40°C; 1 h;
参考文献
WO2013/59587 A1, ;
Page/Page column 186; 187; 194 ;
反应条件
1: in tetrahydrofuran; toluene
T=0 - 20°C;
2: With ammonium chloride in tetrahydrofuran; water; toluene
参考文献
VERNALIS (RandD) LIMITED
Patent: WO2009/156737 A1, 2009 ;
Location in patent: Page/Page column 56 ;
WO 2009/156737 A1
反应条件
1: 74 percent / MnO2 / acetone
2: 72 percent / aq. KOH / tetrahydrofuran
View Scheme
参考文献
Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612
反应条件
hydrazine hydrate in methanol
2 h; Reflux;
参考文献
Chandrasekhar, Vadapalli; Hossain, Sakiat; Das, Sourav; Biswas, Sourav; Sutter, Jean-Pascal
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6346 - 6353
