6-羟甲基吡啶-2-羧酸甲酯合成路线 （共 21 条）
反应条件
sodium tetrahydroborate in methanol; dichloromethane T=0 - 20°C;
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102145 A1, 2013 ;
Location in patent: Paragraph 0333 ;
反应条件
1: With sodium tetrahydroborate in methanol; dichloromethane T=-40 - 20°C; 2: With hydrogenchloride in methanol; dichloromethane; water 0.333333 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/152082 A1, 2009 ;
Location in patent: Page/Page column 213 ;
WO 2009/152082 A1
反应条件
1: 79 percent / H2SO4 / 24 h / Heating 2: 48 percent / sodium borohydride / methanol / 5 h / Heating View Scheme
参考文献
Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612
反应条件
sodium tetrahydroborate in methanol Cooling with ice;
参考文献
Price, Eric W.; Cawthray, Jacqueline F.; Bailey, Gwendolyn A.; Ferreira, Cara L.; Boros, Eszter; Adam, Michael J.; Orvig, Chris
Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8670 - 8683
反应条件
1: 0.5 h / 0 °C / |Reflux 2: sodium tetrahydroborate / methanol / 14 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Polasek, Miloslav; Caravan, Peter
Inorganic Chemistry, 2013 , vol. 52, # 7 p. 4084 - 4096
反应条件
1: air; steam; vanadium(V)-oxide-molybdenum (VI)-oxide /silica gel 2: air; water; molybdenum oxide vanadium oxide catalyst / 400 °C 3: aqueous KOH View Scheme
参考文献
Mathes et al.
Chemische Berichte, 1953 , vol. 86, p. 584,587
反应条件
methanol; aluminum oxide; palladium/alumina
参考文献
Mathes et al.
Chemische Berichte, 1953 , vol. 86, p. 584,587
反应条件
1: air; water; molybdenum oxide vanadium oxide catalyst / 400 °C 2: aqueous KOH View Scheme
参考文献
Mathes et al.
Chemische Berichte, 1953 , vol. 86, p. 584,587
反应条件
1: aqueous KOH View Scheme
参考文献
Mathes et al.
Chemische Berichte, 1953 , vol. 86, p. 584,587
反应条件
1: SeO2; acetic acid 2: palladium/Al2O3; methanol View Scheme
参考文献
Mathes et al.
Chemische Berichte, 1953 , vol. 86, p. 584,587
