(2R)-2-[[(叔丁基)二甲基硅烷基]氧基]科立内酯合成路线 （共 6 条）
反应条件
1: Dess-Martin periodinane; NaHCO3 / CH2Cl2 2: KOtBu / tetrahydrofuran 3: 84 percent / Grubbs' 2nd generation catalyst / CH2Cl2 / 12 h / 40 °C 4: DIBAL-H / CH2Cl2 / -78 °C 5: KOtBu / tetrahydrofuran 6: HCl / tetrahydrofuran / 48 h View Scheme
参考文献
Sheddan, Neil A.; Arion, Vladimir B.; Mulzer, Johann
Tetrahedron Letters, 2006 , vol. 47, # 37 p. 6689 - 6693
反应条件
sodium hydrogencarbonate; Dess-Martin periodane in dichloromethane
Dess-Martin oxidation;
参考文献
Sheddan, Neil A.; Arion, Vladimir B.; Mulzer, Johann
Tetrahedron Letters, 2006 , vol. 47, # 37 p. 6689 - 6693
反应条件
<b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '3684764', constants.ctx, '0')">diethylaluminium chloride</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=-50°C; 2 h; <br />
参考文献
Sheddan, Neil A.; Arion, Vladimir B.; Mulzer, Johann Tetrahedron Letters, 2006 , vol. 47, # 37 p. 6689 - 6693
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: imidazole / dimethylformamide<br />2: Et<sub>2</sub>AlCl / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / -50 °C<br /> <br />
参考文献
Sheddan, Neil A.; Arion, Vladimir B.; Mulzer, Johann Tetrahedron Letters, 2006 , vol. 47, # 37 p. 6689 - 6693
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: K<sub>2</sub>CO<sub>3</sub> / methanol<br />2: imidazole / dimethylformamide<br />3: Et<sub>2</sub>AlCl / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / -50 °C<br /> <br />
参考文献
Sheddan, Neil A.; Arion, Vladimir B.; Mulzer, Johann Tetrahedron Letters, 2006 , vol. 47, # 37 p. 6689 - 6693
反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1: 95 percent / DMAP; Et<sub>3</sub>N / CH<sub>2</sub>Cl<sub>2</sub> <br />2: K<sub>2</sub>CO<sub>3</sub> / methanol<br />3: imidazole / dimethylformamide<br />4: Et<sub>2</sub>AlCl / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / -50 °C<br /> <br />
参考文献
Sheddan, Neil A.; Arion, Vladimir B.; Mulzer, Johann Tetrahedron Letters, 2006 , vol. 47, # 37 p. 6689 - 6693
