2,6-二甲基-4-氰基吡啶合成路线 （共 16 条）
反应条件
1: 86 percent / 2 h / 80 °C 2: 18 percent / H2O / 24 h / 20 °C View Scheme
参考文献
Charier, Sandrine; Ruel, Odile; Baudin, Jean-Bernard; Alcor, Damien; Allemand, Jean-Francois; Meglio, Adrien; Jullien, Ludovic; Valeur, Bernard
Chemistry - A European Journal, 2006 , vol. 12, # 4 p. 1097 - 1113
参考文献
Talik; Plazek
Roczniki Chemii, 1959 , vol. 33, p. 387,392
Chem.Abstr., 1959 , p. 18954
参考文献
Feely; Beavers
Journal of the American Chemical Society, 1959 , vol. 81, p. 4004,4005
反应条件
potassium hydroxide in ethanol 3 h; Heating;
参考文献
Charier, Sandrine; Ruel, Odile; Baudin, Jean-Bernard; Alcor, Damien; Allemand, Jean-Francois; Meglio, Adrien; Jullien, Ludovic; Valeur, Bernard
Chemistry - A European Journal, 2006 , vol. 12, # 4 p. 1097 - 1113
反应条件
sodium hydroxide; dihydrogen peroxide in ethanol; water
T=0°C; 0.5 h;
参考文献
G.D. SEARLE and CO.
Patent: EP1221441 A2, 2002 ;
Location in patent: Page 41, 203 ;
反应条件
1: in diethyl ether
T=0 - 5°C; 2 h; Heating / reflux;
2: With water; ammonium chloride in diethyl ether
T=0 - 5°C;
3: With hydrogenchloride; water; sodium hydrogencarbonate
more than 3 stages;
参考文献
DOV PHARMACEUTICAL, INC.
Patent: WO2005/84439 A1, 2005 ;
Location in patent: Page/Page column 31-32 ;
WO 2005/084439 A1
