N-Cbz-3-哌啶甲醇合成路线 （共 11 条）
反应条件
triethylamine in dichloromethane T=20°C; Cooling;
参考文献
Dou, Dengfeng; Tiew, Kok-Chuan; He, Guijia; Mandadapu, Sivakoteswara Rao; Aravapalli, Sridhar; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 5975 - 5983
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-10°C; 1 h; 2: With sodium hydroxide in tetrahydrofuran; water
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
Location in patent: Page/Page column 44 ;
反应条件
sodium hydroxide in tetrahydrofuran; hexane; water
参考文献
Aquila, Brian M.; Bannister, Thomas D.; Cuny, Gregory C.; Hauske, James R.; Heffernan, Michele L.R.; Hoemann, Michael Z.; Kessler, Donald W.; Shao, Liming; Wu, Xinhe; Xie, Roger L.
Patent: US2002/177721 A1, 2002 ;
反应条件
triethylamine in 1,4-dioxane; water 20 h; Ambient temperature;
参考文献
Fushiya, Shinji; Kanazawa, Toshiyuki; Nozoe, Shigeo
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 11 p. 2089 - 2094
参考文献
Merck and Co., Inc.
Patent: US6329380 B1, 2001 ;
US 6329380 B1
反应条件
1: sodium hydrogencarbonate / water / 16 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 °C View Scheme
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
反应条件
1: sodium hydrogencarbonate / water / 16 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 °C View Scheme
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
反应条件
sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hydrogencarbonate; potassium bromide in dichloromethane; water T=0°C; 0.25 h;
参考文献
Dou, Dengfeng; Tiew, Kok-Chuan; He, Guijia; Mandadapu, Sivakoteswara Rao; Aravapalli, Sridhar; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 5975 - 5983
反应条件
in diethyl ether; hexane; dichloromethane
参考文献
Aquila, Brian M.; Bannister, Thomas D.; Cuny, Gregory C.; Hauske, James R.; Heffernan, Michele L.R.; Hoemann, Michael Z.; Kessler, Donald W.; Shao, Liming; Wu, Xinhe; Xie, Roger L.
Patent: US2002/177721 A1, 2002 ;
反应条件
1: sodium hydrogencarbonate; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane; water / 18 h / 20 °C
2: potassium carbonate; toluene-4-sulfonic acid; toluene-4-sulfonamide / toluene; ethylene glycol dimethyl ether; methanol / 20 h / 80 °C
3: hydrogenchloride / 1,4-dioxane; water / 16 h / 80 °C
View Scheme
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
