1-甲基-2-(苯氧基)苯合成路线 （共 45 条）
反应条件
azoisobutyric acid dinitrile in 1,1,2,2-tetrachloroethylene
参考文献
Bromine Compounds Ltd.
Patent: US4709100 A1, 1987 ;
反应条件
copper diacetate; triethylamine in dichloromethane
T=50°C; 3 h; Sealed tube;
参考文献
Crifar, Cynthia; Petiot, Pauline; Ahmad, Tabinda; Gagnon, Alexandre
Chemistry - A European Journal, 2014 , vol. 20, # 10 p. 2755 - 2760
反应条件
potassium hydroxide; copper
T=150°C; Erhitzen des Reaktionsprodukts mit 2-Brom-toluol auf 220-230grad;
参考文献
Sartoretto; Sowa
Journal of the American Chemical Society, 1937 , vol. 59, p. 603
反应条件
copper
T=160 - 190°C;
参考文献
Suter; Green
Journal of the American Chemical Society, 1937 , vol. 59, p. 2578
反应条件
copper
T=220°C; 3 h;
参考文献
Gobbi, Silvia; Zimmer, Christina; Belluti, Federica; Rampa, Angela; Hartmann, Rolf W.; Recanatini, Maurizio; Bisi, Alessandra
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5347 - 5351
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid; boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 20 °C
1.2: 0.25 h / 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C
2.2: 0.5 h / 40 °C
View Scheme
参考文献
Jalalian, Nazli; Petersen, Tue B.; Olofsson, Berit
Chemistry--A European Journal, 2012 , vol. 18, # 44 p. 14140 - 14149,10
反应条件
1: phenol With sodium hydride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
2: With copper(l) chloride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
3: 1-iodo-2-methylbenzene; 1-(iodo)-4-methylbenzene Further stages;
参考文献
Tye, Jesse W.; Weng, Zhiqiang; Giri, Ramesh; Hartwig, John F.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 12 p. 2185 - 2189
反应条件
1: hydrogen; sodium t-butanolate; [Ni(CH2SiMe3)2(tmen)] / m-xylene / 48 h / 120 °C / 750.08 Torr / |Schlenk technique
2: pyridine-2-carboxylic acid; potassium phosphate; copper(l) iodide / dimethyl sulfoxide / 20 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Sergeev, Alexey G.; Webb, Jonathan D.; Hartwig, John F.
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20226 - 20229
反应条件
1: hydrogen; sodium t-butanolate; [Ni(CH2SiMe3)2(tmen)] / m-xylene; hexane / 41 h / 120 °C / 750.08 Torr / |Schlenk technique
2: pyridine-2-carboxylic acid; potassium phosphate; copper(l) iodide / dimethyl sulfoxide / 20 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Sergeev, Alexey G.; Webb, Jonathan D.; Hartwig, John F.
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20226 - 20229
反应条件
1: hydrogen; sodium t-butanolate; [Ni(CH2SiMe3)2(tmen)] / m-xylene / 48 h / 120 °C / 750.08 Torr / |Schlenk technique
2: pyridine-2-carboxylic acid; potassium phosphate; copper(l) iodide / dimethyl sulfoxide / 20 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Sergeev, Alexey G.; Webb, Jonathan D.; Hartwig, John F.
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20226 - 20229
