2-甲基-4,6-二氯-5-氨基嘧啶合成路线 （共 15 条）
反应条件
trichlorophosphate T=110°C; 20 h; Inert atmosphereSealed tube;
参考文献
ENANTIA, S.L.; PASTÓ AGUILÀ, Mireia; COMELY, Alexander Christian
Patent: WO2014/23681 A1, 2014 ;
Location in patent: Page/Page column 35 ;
反应条件
iron in methanol; acetic acid T=60°C; 2 h;
参考文献
Nemeryuk, M. P.; Sedov, A. L.; Krepelka, I.; Benes, Ya.; Safonova, T. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 1113 - 1115
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 10 p. 1398 - 1400
反应条件
acetic acid in methanol
参考文献
DuPont Pharmaceuticals Company
Patent: US6245769 B1, 2001 ;
US 6245769 B1
反应条件
1: hydrogenchloride / water; methanol / 15.5 h / 20 - 50 °C / |Inert atmosphere 2: trichlorophosphate / 20 h / 110 °C / |Inert atmosphere; |Sealed tube View Scheme
参考文献
ENANTIA, S.L.; PASTÓ AGUILÀ, Mireia; COMELY, Alexander Christian
Patent: WO2014/23681 A1, 2014 ;
反应条件
N,N-diethylaniline; trichlorophosphate
参考文献
Rose; Brown
Journal of the Chemical Society, 1956 , p. 1953,1955
反应条件
1: N,N-diethyl-aniline; POCl3 2: aqueous Fe(OH)2 View Scheme
参考文献
Albert et al.
Journal of the Chemical Society, 1954 , p. 3832,3833
反应条件
1: acetic acid; HNO3 2: N,N-diethyl-aniline; POCl3 3: aqueous Fe(OH)2 View Scheme
参考文献
Albert et al.
Journal of the Chemical Society, 1954 , p. 3832,3833
反应条件
palladium on activated charcoal; ethanol; magnesium oxide Hydrogenation;
参考文献
Urban; Schnider
Helvetica Chimica Acta, 1958 , vol. 41, p. 1806,1812
参考文献
Wirth, David D; He, Minxia M; Czeskis, Boris A; Zimmerman, Karen M; Roettig, Ulrike; Stenzel, Wolfgang; Steinberg, Mitchell I
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 1 p. 23 - 34
反应条件
sodium methylate 12 h; Ambient temperature;
参考文献
Nemeryuk, M. P.; Sedov, A. L.; Krepelka, I.; Benes, Ya.; Safonova, T. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 1113 - 1115
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 10 p. 1398 - 1400
