thionyl chloride 48 h; Ambient temperature;

1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / N,N-dimethyl-formamide; dichloromethane / 1.5 h / -15 °C / |Darkness 1.2: 3 h / 20 °C / |Darkness 2.1: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 - 20 °C / |Inert atmosphere; |Darkness 3.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / |Darkness 4.1: ethanol / 1.5 h / |Reflux; |Darkness 5.1: pH 7.4 / |UV-irradiation View Scheme

1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / |Darkness 2: ethanol / 1.5 h / |Reflux; |Darkness 3: pH 7.4 / |UV-irradiation View Scheme

pH=7.4; UV-irradiation;

triethylamine in dichloromethane T=0 - 20°C; 1.25 h;

triethylamine in tetrahydrofuran T=20°C; 2 h;

triethylamine in tetrahydrofuran T=20°C; 12 h;

1.1: tetrahydrofuran / 168 h / 23 °C / |Inert atmosphere 2.1: methanesulfonic acid / toluene / 16 h / |Inert atmosphere; |Reflux 2.2: |Inert atmosphere View Scheme

N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 0.25 h;

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