2-氯-6-三氟甲基吡啶合成路线 （共 27 条）
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=25°C; 6 h;
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2002 , # 2 p. 327 - 330
反应条件
1.1: iPrMgCl / tetrahydrofuran / 2 h / 0 - 25 °C 1.2: 73 percent / CF2ClCFCl2 / tetrahydrofuran / 1.75 h / 0 - 25 °C 2.1: nBuLi / diethyl ether; hexane / 0.75 h / -75 °C 2.2: 84 percent / I2 / hexane; diethyl ether; tetrahydrofuran / 0.75 h / -75 °C 3.1: 59 percent / KF; CuI / dimethylformamide; 1-methyl-pyrrolidin-2-one / 6 h / 25 °C View Scheme
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2002 , # 2 p. 327 - 330
反应条件
1.1: nBuLi / diethyl ether; hexane / 0.75 h / -75 °C 1.2: 84 percent / I2 / hexane; diethyl ether; tetrahydrofuran / 0.75 h / -75 °C 2.1: 59 percent / KF; CuI / dimethylformamide; 1-methyl-pyrrolidin-2-one / 6 h / 25 °C View Scheme
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2002 , # 2 p. 327 - 330
反应条件
hydrogenchloride in water
参考文献
Zeneca Limited
Patent: US6143899 A1, 2000 ;
反应条件
potassium hydroxide; sodium chloride
参考文献
Zeneca Limited
Patent: US5973159 A1, 1999 ;
参考文献
Zeneca Limited
Patent: US5973159 A1, 1999 ;
反应条件
isobutyramide; copper T=100°C; 8 h;
参考文献
Clark, James H.; Denness, James E.; McClinton, Martin A.; Wynd, Andrew J.
Journal of Fluorine Chemistry, 1990 , vol. 50, # 3 p. 411 - 426
反应条件
ammonium hydroxide T=180°C;
参考文献
The Boots Company PLC
Patent: US5464781 A1, 1995 ;
反应条件
1: H2, N,N-dimethylethylamine / 10percent Pd/C / methyl acetate / 1.5 h 2: H2O2, acetic acid 3: 38 percent / conc. H2SO4, fuming HNO3 / 3.5 h / 125 - 130 °C View Scheme
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
反应条件
dimethylethylamine; hydrogen; palladium on activated charcoal in methyl acetate 1.5 h;
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
