5-(3-溴苯基)呋喃-2-甲醛合成路线 （共 3 条）
反应条件
1: 3-bromo-aniline With hydrogenchloride; sodium nitrite in water
T=0 - 110°C; Meerwein Arylation; 0.333333 h;
2: furfural in water; acetone
T=0°C; Meerwein Arylation; 0.25 h;
3: With copper dichloride in water; acetone
T=0 - 20°C; Meerwein Arylation; 14 h;
参考文献
Murasawa, Shinpei; Sato, Shinichi; Noguchi-Yachide, Tomomi; Hashimoto, Yuichi; Iuchi, Katsuya; Sodeoka, Mikiko; Dodo, Kosuke; Yokomatsu, Tsutomu; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6384 - 6393,10
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
2 h; Reflux;
参考文献
Kyoto University; Nihon Medi-Physics Co., Ltd.
Patent: US2012/330024 A1, 2012 ;
Location in patent: Page/Page column 6 ;
US 20120330024 A1
反应条件
CuCl2*2H2O in water; acetone
T=15 - 18°C; pH 4-6;
参考文献
Obushak, N. D.; Lesyuk, A. I.; Ganushchak, N. I.; Mel'nik, G. M.; Zavalii, P. Yu.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2093 - 2097
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2331 - 2336
