9-[4-羟基-3-(羟甲基)-丁基]-鸟嘌呤合成路线 （共 58 条）
反应条件
1.1: sodium acetate / 4 h / 70 °C 2.1: sodium bromide; HCl / dimethylformamide / 8 h / 70 °C 3.1: 15.1 g / HCl / dimethylformamide / 3 h / 40 °C 4.1: 95.7 percent / AcOH; p-TsOH*H2O / 3 h / 105 °C 5.1: 1-methyl-pyrrolidin-2-one / 18 h / 80 °C 6.1: hydrogen; K2CO3 / Pd-C / H2O; methanol; 1-methyl-pyrrolidin-2-one / 21.5 h / 45 °C / 760 Torr 6.2: 2.58 g / NaOH / H2O / 2 h / 50 °C / pH 13.0 View Scheme
参考文献
Torii, Takayoshi; Shiragami, Hiroshi; Yamashita, Keizo; Suzuki, Yumiko; Hijiya, Toyoto; Kashiwagi, Tatsuki; Izawa, Kunisuke
Tetrahedron, 2006 , vol. 62, # 24 p. 5709 - 5716
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 4 h / 150 °C 2.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 3.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 3.2: NH4OH / 1 h / Heating 4.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 5.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 6.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 7.1: aq. NaOH / 0.5 h / Heating View Scheme
参考文献
Brand, Briony; Reese, Colin B.; Song, Quanlai; Visintin, Cristina
Tetrahedron, 1999 , vol. 55, # 16 p. 5239 - 5252
反应条件
sodium hydroxide T=90°C; 3 h;
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=20°C; 48 h;
参考文献
Geen, Graham R.; Kincey, Peter M.; Spoors, P. Grant
Tetrahedron Letters, 2001 , vol. 42, # 9 p. 1781 - 1784
反应条件
1.1: sodium bromide; HCl / dimethylformamide / 8 h / 70 °C 2.1: 15.1 g / HCl / dimethylformamide / 3 h / 40 °C 3.1: 95.7 percent / AcOH; p-TsOH*H2O / 3 h / 105 °C 4.1: 1-methyl-pyrrolidin-2-one / 18 h / 80 °C 5.1: hydrogen; K2CO3 / Pd-C / H2O; methanol; 1-methyl-pyrrolidin-2-one / 21.5 h / 45 °C / 760 Torr 5.2: 2.58 g / NaOH / H2O / 2 h / 50 °C / pH 13.0 View Scheme
参考文献
Torii, Takayoshi; Shiragami, Hiroshi; Yamashita, Keizo; Suzuki, Yumiko; Hijiya, Toyoto; Kashiwagi, Tatsuki; Izawa, Kunisuke
Tetrahedron, 2006 , vol. 62, # 24 p. 5709 - 5716
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Brand, Briony; Reese, Colin B.; Song, Quanlai; Visintin, Cristina
Tetrahedron, 1999 , vol. 55, # 16 p. 5239 - 5252
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Brand, Briony; Reese, Colin B.; Song, Quanlai; Visintin, Cristina
Tetrahedron, 1999 , vol. 55, # 16 p. 5239 - 5252
反应条件
1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 2: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 3: HCOONH4 / Pd/C / methanol / 4 h / Heating 4: aq. NaOH / 0.5 h / Heating View Scheme
参考文献
Kalayanov, Genadiy; Jaksa, Suzana; Scarcia, Tommaso; Kobe, Joze
Synthesis, 2004 , # 12 p. 2026 - 2034
反应条件
1.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 2.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 2.2: NH4OH / 1 h / Heating 3.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 4.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 5.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 6.1: aq. NaOH / 0.5 h / Heating View Scheme
参考文献
Kalayanov, Genadiy; Jaksa, Suzana; Scarcia, Tommaso; Kobe, Joze
Synthesis, 2004 , # 12 p. 2026 - 2034
反应条件
1.1: H2; NaHCO3 / Pd/C / methanol; H2O / 19 h / 50 °C / 760.05 Torr 1.2: 90 percent / aq. NaOH / methanol / 2 h / 60 °C 2.1: 95 percent / thionyl chloride / 40 - 45 °C 3.1: 78 percent / sodium borohydride / propan-2-ol; H2O / 2.5 h / 40 °C View Scheme
参考文献
Torii, Takayoshi; Yamashita, Keizo; Kojima, Mitsuhiko; Suzuki, Yumiko; Hijiya, Toyoto; Izawa, Kunisuke
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 4-6 p. 625 - 634
