9-[4-羟基-3-(羟甲基)-丁基]-鸟嘌呤合成路线 （共 58 条）
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Zheng, Qi-Huang; Wang, Ji-Quan; Liu, Xuan; Fei, Xiangshu; Mock, Bruce H.; Glick-Wilson, Barbara E.; Sullivan, Michael L.; Raikwar, Sudhanshu P.; Gardner, Thomas A.; Kao, Chinghai; Hutchins, Gary D.
Synthetic Communications, 2004 , vol. 34, # 4 p. 689 - 704
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
ammonia; palladium in formic acid; water
参考文献
Astra Lakemedel Aktiebolag
Patent: US4798833 A1, 1989 ;
US 4798833 A
反应条件
sodium tetrahydroborate in water; isopropyl alcohol T=40°C; 2.5 h;
参考文献
Torii, Takayoshi; Yamashita, Keizo; Kojima, Mitsuhiko; Suzuki, Yumiko; Hijiya, Toyoto; Izawa, Kunisuke
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 4-6 p. 625 - 634
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
Astra Lakemedel Aktiebolag
Patent: US4798833 A1, 1989 ;
US 4798833 A
反应条件
1.1: 74 percent / dimethylformamide; H2O / 8 h / 70 °C 2.1: H2; NaHCO3 / Pd/C / methanol; H2O / 19 h / 50 °C / 760.05 Torr 2.2: 90 percent / aq. NaOH / methanol / 2 h / 60 °C 3.1: 95 percent / thionyl chloride / 40 - 45 °C 4.1: 78 percent / sodium borohydride / propan-2-ol; H2O / 2.5 h / 40 °C View Scheme
参考文献
Torii, Takayoshi; Shiragami, Hiroshi; Yamashita, Keizo; Suzuki, Yumiko; Hijiya, Toyoto; Kashiwagi, Tatsuki; Izawa, Kunisuke
Tetrahedron, 2006 , vol. 62, # 24 p. 5709 - 5716
反应条件
1: NaBH4 / 2-methyl-propan-2-ol; methanol 2: p-toluenesulfonic acid / tetrahydrofuran 3: CBr4; PPh3 / tetrahydrofuran / 0 °C 4: K2CO3 / dimethylformamide 5: HCl View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: p-toluenesulfonic acid / tetrahydrofuran 2: CBr4; PPh3 / tetrahydrofuran / 0 °C 3: K2CO3 / dimethylformamide 4: HCl View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: CBr4; PPh3 / tetrahydrofuran / 0 °C 2: K2CO3 / dimethylformamide 3: HCl View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: K2CO3 / dimethylformamide 2: HCl View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
