2-甲基-5-三氟甲基苯并噻唑合成路线 （共 5 条）
反应条件
1: pyridine / 2 h / 120 °C 2: phosphorus pentasulfide / benzene / 3 h / Heating 3: NaH / toluene / 0.5 h / Heating View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
1: phosphorus pentasulfide / benzene / 3 h / Heating 2: NaH / toluene / 0.5 h / Heating View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
hydrogenchloride; acetic acid; zinc anschliessendes Erhitzen mit Acetanhydrid;
参考文献
Kiprianow; Jagupol'skii
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 2209,2214; engl. Ausg. S. 2267, 2271
参考文献
Kiprianow; Jagupol'skii
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 2209,2214; engl. Ausg. S. 2267, 2271
反应条件
sodium hydroxide in ethylene glycol T=125°C; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3141 - 3152
