6-氟-2H-1,4-苯并嗪-3(4H)-酮合成路线 (共 8 条)
反应条件
1: With iron; acetic acid T=20°C; 2: With sodium hydrogencarbonate; sodium hydroxide pH=7;
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
Location in patent: Page/Page column 32 ;
反应条件
iron; acetic acid 2.5 h; Inert atmosphereReflux;
参考文献
Ramesh, Chintakunta; Raju, B. Rama; Kavala, Veerababurao; Kuo, Chun-Wei; Yao, Ching-Fa
Tetrahedron, 2011 , vol. 67, # 6 p. 1187 - 1192
反应条件
nickel monoaluminide in methanol
参考文献
Carbipem
Patent: US4755509 A1, 1988 ;
反应条件
hydrogenchloride; iron
参考文献
Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
反应条件
1: concentrated aqueous nitric acid; sulfuric acid 2: iron-powder; aqueous HCl View Scheme
参考文献
Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
反应条件
1: potassium carbonate / acetone / Inert atmosphere; Reflux 2: iron; acetic acid / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide
参考文献
Geng, Bolin; Comita-Prevoir, Janelle; Eyermann, Charles J.; Reck, Folkert; Fisher, Stewart
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5432 - 5435
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
Location in patent: Page/Page column 32; 33 ;