反应条件
1: 4-bromo-pyridine With n-butyllithium in tetrahydrofuran; pentane T=-78°C; Metallation; 0.166667 h; 2: With zinc(II) chloride in tetrahydrofuran; diethyl ether; pentane T=-78 - 20°C; Substitution; 2 h; 3: 4-bromo-1-iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Arylation; 72 h;
参考文献
Choi-Sledeski, Yong Mi; McGarry, Daniel G.; Green, Daniel M.; Mason, Helen J.; Becker, Michael R.; Davis, Roderick S.; Ewing, William R.; Dankulich, William P.; Manetta, Vincent E.; Morris, Robert L.; Spada, Alfred P.; Cheney, Daniel L.; Brown, Karen D.; Colussi, Dennis J.; Valeria, Chu; Heran, Christopher L.; Morgan, Suzanne R.; Bentley, Ross G.; Leadley, Robert J.; Maignan, Sebastien; Guilloteau, Jean-Pierre; Dunwiddie, Christopher T.; Pauls, Henry W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3572 - 3587