1,3-二甲基-2-苯基苯合成路线 （共 66 条）
反应条件
tetrabutyl ammonium fluoride; triphenylphosphine; palladium diacetate in tetrahydrofuran; N,N-dimethyl-formamide
T=83°C; 23.5 h;
参考文献
Mowery; DeShong
Organic letters, 1999 , vol. 1, # 13 p. 2137 - 2140
反应条件
1: phenyl-magnesium chloride With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane
T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere;
2: 2,6-Me2C6H3OTs in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Kapdi, Anant R.; Fenner, Sabine; Kornhaab, Christoph; Schulzke, Carola
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2965 - 2971
反应条件
tetrabutyl ammonium fluoride; bis(dibenzylideneacetone)-palladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane
6 h; Heating;
参考文献
Seganish, W. Michael; DeShong, Philip
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1137 - 1143
反应条件
1: 2,6-dimethylbenzeneamine With hydrogenchloride in water
T=0 - 5°C;
2: With sodium tetrafluoroborate; sodium nitrite in water
T=5°C; 0.166667 h;
3: diphenyldimethoxysilane With methanol; palladium diacetate
T=25°C; Hiyama coupling; 6 h;
参考文献
Cheng, Kai; Wang, Chen; Ding, Yiyuan; Song, Qingbao; Qi, Chenze; Zhang, Xian-Man
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9261 - 9268
反应条件
tetrabutyl ammonium fluoride; palladium dichloride in tetrahydrofuran
T=70°C; Hiyama Coupling; 3 h;
参考文献
Cheng, Kai; Hu, Sai; Zhao, Baoli; Zhang, Xian-Man; Qi, Chenze
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 5022 - 5025
反应条件
palladium diacetate; caesium carbonate; tri-cyclo-hexyl-phosphine in o-xylene
8 h; Heating;
参考文献
Terao, Yoshito; Wakui, Hiroyuki; Nomoto, Michiyo; Satoh, Tetsuya; Miura, Masahiro; Nomura, Masakatsu
Journal of Organic Chemistry, 2003 , vol. 68, # 13 p. 5236 - 5243
反应条件
potassium phosphate; Ni(PCy3)2Cl2 in toluene
T=180°C; Suzuki-Miyaura cross-coupling; 0.166667 h; Microwave irradiationInert atmosphere;
参考文献
Baghbanzadeh, Mostafa; Pilger, Christian; Kappe, C. Oliver
Journal of Organic Chemistry, 2011 , vol. 76, # 5 p. 1507 - 1510
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.83 h / -78 °C
1.2: 38 g / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 83 percent / p-toluenesulfonic acid*H2O / methanol / 16 h / 20 °C
3.1: 95 percent / tetrahydrofuran; diethyl ether / -78 - 20 °C
4.1: 94 percent / K2CO3; N-(2-diphenylphosphinobenzylidene)cyclohexylamine; PdCl2 / dimethylsulfoxide; H2O / 13 h / 50 °C
View Scheme
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Sahoo, Akhila K.; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6952 - 6953
反应条件
1.1: aq. HCl / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.83 h / -78 °C
2.2: 38 g / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 83 percent / p-toluenesulfonic acid*H2O / methanol / 16 h / 20 °C
4.1: 95 percent / tetrahydrofuran; diethyl ether / -78 - 20 °C
5.1: 94 percent / K2CO3; N-(2-diphenylphosphinobenzylidene)cyclohexylamine; PdCl2 / dimethylsulfoxide; H2O / 13 h / 50 °C
View Scheme
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Sahoo, Akhila K.; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6952 - 6953
反应条件
1: 95 percent / tetrahydrofuran; diethyl ether / -78 - 20 °C
2: 94 percent / K2CO3; N-(2-diphenylphosphinobenzylidene)cyclohexylamine; PdCl2 / dimethylsulfoxide; H2O / 13 h / 50 °C
View Scheme
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Sahoo, Akhila K.; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6952 - 6953
