1,3-二甲基-2-苯基苯合成路线 （共 66 条）
反应条件
P(i-BuNCH2CH2)3N; tetramethyl-ammonium fluoride; tris(dibenzylideneacetone)dipalladium (0) in 1,4-dioxane
T=100 - 110°C; Stille reaction; 48 h;
参考文献
Su, Weiping; Urgaonkar, Sameer; Verkade, John G.
Organic Letters, 2004 , vol. 6, # 9 p. 1421 - 1424
反应条件
C47H50ClN2P2Pd; cesium fluoride in tetrahydrofuran
Suzuki coupling; 20 h; RefluxInert atmosphere;
参考文献
Snead, David R.; Inagaki, Sebastien; Abboud, Khalil A.; Hong, Sukwon
Organometallics, 2010 , vol. 29, # 7 p. 1729 - 1739
反应条件
potassium tert-butylate in isopropyl alcohol
T=20°C; Suzuki-Miyaura reaction; 15 h; Inert atmosphere;
参考文献
Yokoyama, Naota; Nakayama, Yuji; Nara, Hideki; Sayo, Noboru
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2083 - 2088
反应条件
tris(dibenzylideneacetone)dipalladium (0); Ipr.HCl in tetrahydrofuran; 1,4-dioxane
T=80°C; Phenylation; 5 h;
参考文献
Huang, Jinkun; Nolan, Steven P.
Journal of the American Chemical Society, 1999 , vol. 121, # 42 p. 9889 - 9890
反应条件
tetrabutyl ammonium fluoride; palladium dichloride; tri-cyclo-hexyl-phosphine in water; dimethyl sulfoxide
T=80°C; 4 h;
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
1: PTAS With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
2: 2-Chloro-1,3-dimethylbenzene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water
T=80°C; 12 h;
参考文献
Sahoo, Akhila K.; Nakao, Yoshiaki; Hiyama, Tamejiro
Chemistry Letters, 2004 , vol. 33, # 5 p. 632 - 633
反应条件
tetrabutyl ammonium fluoride in water; toluene
T=100°C; Hiyama Coupling; 20 h;
参考文献
Diebold, Carine; Derible, Antoine; Becht, Jean-Michel; Le Drian, Claude
Tetrahedron, 2013 , vol. 69, # 1 p. 264 - 267
反应条件
lithium chloride; PEPPSI-IPr catalyst in tetrahydrofuran; 1,3-dimethyl-2-imidazolidinone (DMI)
T=20°C; Kumada Coupling Reaction; 1 h; Product distribution / selectivity;
参考文献
Total Synthesis, Ltd.
Patent: US2007/73055 A1, 2007 ;
Location in patent: Page/Page column 13-14; 22 ;
反应条件
dpca; potassium carbonate; palladium dichloride in water; dimethyl sulfoxide
T=50°C; 13 h;
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Sahoo, Akhila K.; Yada, Akira; Hiyama, Tamejiro
Journal of the American Chemical Society, 2005 , vol. 127, # 19 p. 6952 - 6953
反应条件
disodium hydrogenphosphate; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 in water; N,N-dimethyl-formamide
T=120°C; Suzuki-Miyaura coupling; 0.166667 h; Microwave irradiation;
参考文献
Chalker, Justin M.; Wood, Charlotte S. C.; Davis, Benjamin G.
Journal of the American Chemical Society, 2009 , vol. 131, # 45 p. 16346 - 16347
