2-氯-3-氨基-6-甲基吡啶合成路线 （共 11 条）
反应条件
hydrazine hydrate; nickel in ethanol 70 deg C, 10 min; room temperature, 0.5 h;
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1: POCl3, PCl5 / 3 h / Heating 2: conc. ammonium hydroxide / CHCl3 / 0 °C 3: 1.4 g / Br2, aq. NaOH / 1.) 0 deg C, 15 min, 2.) 75 deg C, 45 min View Scheme
参考文献
Tomczuk, Bruce E.; Taylor, C. R; Moses, L. Meredith; Sutherland, Deborah B.; Lo, Young S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 2993 - 3006
反应条件
1: conc. ammonium hydroxide / CHCl3 / 0 °C 2: 1.4 g / Br2, aq. NaOH / 1.) 0 deg C, 15 min, 2.) 75 deg C, 45 min View Scheme
参考文献
Tomczuk, Bruce E.; Taylor, C. R; Moses, L. Meredith; Sutherland, Deborah B.; Lo, Young S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 2993 - 3006
反应条件
1: liquid NH3; xylene; Fe(NO3)3 2: concentrated H2SO4; concentrated HNO3 3: sodium nitrite; aqueous hydrochloric acid / Diazotization 4: SnCl2; concentrated aqueous HCl View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
1: concentrated H2SO4; concentrated HNO3 2: sodium nitrite; aqueous hydrochloric acid / Diazotization 3: SnCl2; concentrated aqueous HCl View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
1: sodium nitrite; aqueous hydrochloric acid / Diazotization 2: SnCl2; concentrated aqueous HCl View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
sodium hydroxide; bromine 1.) 0 deg C, 15 min, 2.) 75 deg C, 45 min;
参考文献
Tomczuk, Bruce E.; Taylor, C. R; Moses, L. Meredith; Sutherland, Deborah B.; Lo, Young S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 2993 - 3006
反应条件
dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate in 1,4-dioxane T=50°C; 24 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Surry, David S.; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 14 p. 3734 - 3737
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite T=50°C; 0.166667 h;
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1: pyridine / dioxane; cyclohexane / Ambient temperature 2: xylene / Heating 3: NaH / various solvent(s) / Heating 4: 1.) NaH / 1.) DMSO, 2.) DMSO View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
