N-(2-苯乙基)-4-哌啶酮合成路线 （共 32 条）
反应条件
1.1: acetic acid / methanol / |Reflux 2.1: sodium; methanol / toluene / |Reflux 3.1: hydrogenchloride / water / |Reflux 3.2: 20 °C View Scheme
参考文献
Sun, Chuan-Wen; Wang, Hai-Feng; Zhu, Jun; Yang, Ding-Rong; Xing, Jiahua; Jin, Jia
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1374 - 1380
反应条件
1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH4 / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h 2: 10.04 g / toluene / 3 h / Heating View Scheme
参考文献
Brine; Boldt; Huang; Sawyer; Carroll
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 677 - 686
反应条件
palladium in thiophene; methanol
参考文献
The Upjohn Company
Patent: US4481360 A1, 1984 ;
US 4481360 A
反应条件
ammonia; hydrogen; palladium on activated charcoal in methanol
参考文献
Lobbezoo; Soudijn; Van Wijngaarden
Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 777 - 782
反应条件
1: sodium triacetoxyborohydride; acetic acid / CH2Cl2 / 24 h / 20 °C 2: 13.44 g / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Brine; Boldt; Huang; Sawyer; Carroll
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 677 - 686
反应条件
in methanol; water Ambient temperature;
参考文献
Iorio; Molinari; Scotti de Carolis; Niglio
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 7 p. 599 - 611
反应条件
1: ZnI2 / 1.) 0 deg C, 3 h, 2.) 60 deg C, 3 h 2: LiAlH4 / diethyl ether / 2 h 3: 69 percent / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Somanathan; Rivero; Nunez; Hellberg
Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
反应条件
1: p-toluene sulfonic acid / toluene / 5 h / Heating; Dean-Stark trap 2: sodium borohydride / methanol / 2 h / Heating View Scheme
参考文献
Ulens; Van Boven; Daenens; Tytgat
Journal of Pharmacology and Experimental Therapeutics, 2000 , vol. 294, # 3 p. 1024 - 1033
反应条件
sodium tetrahydroborate; toluene-4-sulfonic acid 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h; Yield given. Multistep reaction;
参考文献
Brine; Boldt; Huang; Sawyer; Carroll
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 677 - 686
反应条件
1: ZnI2 / 1.) 0 deg C, 3 h, 2.) 60 deg C, 3 h 2: LiAlH4 / diethyl ether / 2 h View Scheme
参考文献
Somanathan; Rivero; Nunez; Hellberg
Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
