4-氨基-2-甲基硫代噻唑-5-甲腈合成路线 （共 5 条）
反应条件
triethylamine in acetone
参考文献
Walek,W. et al.
Tetrahedron, 1976 , vol. 32, p. 623 - 627
反应条件
1: dimethyl N-cyano-dithioimidocarbonate With sodium sulfide in N,N-dimethyl-formamide
T=70°C; 2 h;
2: chloroacetonitrile in N,N-dimethyl-formamide
T=70°C; 2 h;
3: With potassium carbonate in N,N-dimethyl-formamide
T=70°C; 1 h; Further stages.;
参考文献
Thomae, David; Perspicace, Enrico; Hesse, Stephanie; Kirsch, Gilbert; Seck, Pierre
Tetrahedron, 2008 , vol. 64, # 39 p. 9309 - 9314
反应条件
triethylamine in acetone
T=20°C; 72 h;
参考文献
Lin, Ronghui; Johnson, Sigmond G.; Connolly, Peter J.; Wetter, Steven K.; Binnun, Eva; Hughes, Terry V.; Murray, William V.; Pandey, Niranjan B.; Moreno-Mazza, Sandra J.; Adams, Mary; Fuentes-Pesquera, Angel R.; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 8 p. 2333 - 2337
反应条件
potassium hydroxide in water; N,N-dimethyl-formamide
0.25 h;
参考文献
Evers, R.
Journal fuer Praktische Chemie (Leipzig), 1985 , vol. 327, # 4 p. 604 - 608
反应条件
sulfuric acid
T=20°C; 1 h;
参考文献
AMBIT BIOSCIENCES CORPORATION; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ROWBOTTOM, Martin
Patent: WO2012/30924 A1, 2012 ;
Location in patent: Page/Page column 156 ;
WO 2012/030924 A1
