1-溴-2-氯-3-硝基苯合成路线 (共 9 条)
反应条件
bromine; mercury(II) oxide in tetrachloromethane 3.5 h; HeatingIrradiation;
参考文献
Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397
反应条件
Diazotization.Eintropfen der Diazoniumloesung in Kupferchloruerloesung;
参考文献
GLAXO GROUP LIMITED; CHAMBERS, Laura Jane; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; STEADMAN, Jon Graham Anthony; WALTER, Daryl Simon
Patent: WO2010/125103 A1, 2010 ;
Location in patent: Page/Page column 78 ;
WO 2010/125103 A1
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=65°C; 0.5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1847541 A1, 2007 ;
Location in patent: Page/Page column 71-72 ;
EP 1847541 A1
反应条件
bromine in tetrachloromethane
参考文献
Costales, Abran Q.; Huang, Shenlin; Jin, Jeff (Xianming); Liu, Zuosheng; Pecchi, Sabina; Poon, Daniel; Tellew, John
Patent: US2011/52578 A1, 2011 ;
反应条件
tetrabutylammonium bromchlorocuprate(I) in chlorobenzene T=90°C; halogen exchange reaction of 3-bromo-2-iodonitrobenzene with tetrabutylammonium bromochlorocuprate(I), NMR study; Rate constant;
参考文献
Koerner; Contardi
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1906 , vol. <5> 15 I, p. 526
反应条件
1: nitric acid 2: alcohol; ammonia / 180 °C 3: Diazotization.Eintropfen der Diazoniumloesung in Kupferchloruerloesung View Scheme
参考文献
Koerner; Contardi
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1906 , vol. <5> 15 I, p. 526
反应条件
tetrabutylammonium bromchlorocuprate(I) in chlorobenzene T=90°C; halogen exchange reaction of 3-bromo-2-iodonitrobenzene with tetrabutylammonium bromochlorocuprate(I), NMR study; Rate constant;
参考文献
Liedholm, Brita
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 4 p. 237 - 241
反应条件
potassium fluoride; cesium fluoride in N,N-dimethyl-formamide
参考文献
Vara Prasad; Boyer, Frederick E.; Chupak, Lou; Dermyer, Michael; Ding, Qizhu; Gavardinas; Hagen, Susan E.; Huband, Michael D.; Jiao, Wenhua; Kaneko, Takushi; Maiti, Samarendra N.; Melnick, Michael; Romero, Karina; Patterson; Wu, Xiujuan
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5392 - 5397
反应条件
methanol T=100°C; 3 h; Autoclave;
参考文献
GLAXO GROUP LIMITED; CHAMBERS, Laura Jane; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; STEADMAN, Jon Graham Anthony; WALTER, Daryl Simon
Patent: WO2010/125103 A1, 2010 ;
Location in patent: Page/Page column 78-79 ;
WO 2010/125103 A1