4-甲基-1,3,4,5-四氢-2H-1,5-苯并二氮杂卓-2-酮合成路线 (共 8 条)
反应条件
sodium methylate in methanol 48 h; Reflux;
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe
Patent: WO2012/151512 A2, 2012 ;
Location in patent: Page/Page column 178 ;
反应条件
aluminum oxide 0.0111111 h; microwave irradiation;
参考文献
Kidwai; Ruby; Venkataramanan
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 5 p. 631 - 634
反应条件
triethylamine in tetrahydrofuran 2.5 h; Heating;
参考文献
Wang, Xiaoxia; Li, Zhifang; Zhu, Xiangming; Mao, Hui; Zou, Xuefei; Kong, Lichun; Li, Xinsheng
Tetrahedron, 2008 , vol. 64, # 27 p. 6510 - 6521
参考文献
Cohen; Jin; Reba
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 835 - 837
反应条件
1: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 3 h / 20 °C 2: sodium methylate / methanol / 48 h / Reflux View Scheme
反应条件
methanol; nickel Hydrogenation;
参考文献
Chemische Berichte, , vol. 90, p. 815,822
参考文献
Chemische Berichte, , vol. 92, p. 2902,2912
反应条件
tetraphosphorus decasulfide in pyridine
T=120°C; 0.5 h; Product distribution / selectivity;
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe
Patent: WO2012/151512 A2, 2012 ;
Location in patent: Page/Page column 121; 179 ;