(R)-(-)-α-甲氧基苯乙酸合成路线 （共 47 条）
反应条件
1: Et3N; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 24 h / 20 °C 2: hydrobromic acid / acetic acid / 1 h / 100 °C View Scheme
参考文献
Fujiwara, Tomoya; Sasaki, Masaki; Omata, Kenji; Kabuto, Chizuko; Kabuto, Kuninobu; Takeuchi, Yoshio
Tetrahedron Asymmetry, 2004 , vol. 15, # 3 p. 555 - 563
反应条件
1: 91 percent / DMAP; Et3N / CH2Cl2 / 2 h / 20 °C 2: 85 percent / t-BuOK / acetonitrile / 12 h / 20 °C 3: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 4: 79 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Moreno-Dorado, F. Javier; Guerra, Francisco M.; Ortega, Maria J.; Zubia, Eva; Massanet, Guillermo M.
Tetrahedron Asymmetry, 2003 , vol. 14, # 4 p. 503 - 510
反应条件
1: 85 percent / t-BuOK / acetonitrile / 12 h / 20 °C 2: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 3: 79 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Moreno-Dorado, F. Javier; Guerra, Francisco M.; Ortega, Maria J.; Zubia, Eva; Massanet, Guillermo M.
Tetrahedron Asymmetry, 2003 , vol. 14, # 4 p. 503 - 510
反应条件
1: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 2: 79 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Moreno-Dorado, F. Javier; Guerra, Francisco M.; Ortega, Maria J.; Zubia, Eva; Massanet, Guillermo M.
Tetrahedron Asymmetry, 2003 , vol. 14, # 4 p. 503 - 510
反应条件
sodium carbonate in water; acetonitrile T=25°C; Rate constant;
参考文献
Fornasier, Roberto; Scrimin, Paolo; Tonellato, Umberto
Tetrahedron Letters, 1983 , vol. 24, # 49 p. 5541 - 5542
反应条件
hydrogenchloride 20 h; Heating; Yield given;
参考文献
Jourdain, Franck; Hirokawa, Takahiko; Kogane, Tamizo
Tetrahedron Letters, 1999 , vol. 40, # 12 p. 2307 - 2310
反应条件
1: 22 percent / 5 h / 27 °C / baker's yeast 2: 51 percent / BF3*Et2O 3: 50 percent / NaIO4, RuCl3 View Scheme
参考文献
Takeshita; Akutsu
Tetrahedron Asymmetry, 1992 , vol. 3, # 11 p. 1381 - 1384
反应条件
1: 51 percent / BF3*Et2O 2: 50 percent / NaIO4, RuCl3 View Scheme
参考文献
Takeshita; Akutsu
Tetrahedron Asymmetry, 1992 , vol. 3, # 11 p. 1381 - 1384
反应条件
1: 76 percent / 30percent H2O2, NaOH 2: 22 percent / 5 h / 27 °C / baker's yeast 3: 51 percent / BF3*Et2O 4: 50 percent / NaIO4, RuCl3 View Scheme
参考文献
Takeshita; Akutsu
Tetrahedron Asymmetry, 1992 , vol. 3, # 11 p. 1381 - 1384
参考文献
Mc Kenzie
Journal of the Chemical Society, 1899 , vol. 75, p. 761
