(R)-(-)-α-甲氧基苯乙酸合成路线 (共 47 条)
反应条件
RuCl2 in tetrachloromethane; water; acetonitrile
参考文献
Senapati, Bidyut Kumar; Lee, Sungil; Ryu, Do Hyun; Hwang, Geum-Sook
Angewandte Chemie, International Edition, 2009 , vol. 48, # 24 p. 4398 - 4401
反应条件
sodium periodate; ruthenium trichloride in tetrachloromethane; water; acetonitrile 2 h; Ambient temperature;
参考文献
Takano, Seiichi; Yanase, Masashi; Ogasawara, Kunio
Synthesis, 1989 , # 1 p. 39 - 40
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile T=55°C; 4 h;
参考文献
Moreno-Dorado, F. Javier; Guerra, Francisco M.; Ortega, Maria J.; Zubia, Eva; Massanet, Guillermo M.
Tetrahedron Asymmetry, 2003 , vol. 14, # 4 p. 503 - 510
反应条件
sodium chlorite; sodium dihydrogenphosphate in water; tert-butyl alcohol
参考文献
Prasad, Kavirayani R.; Chandrakumar, Appayee
Tetrahedron Asymmetry, 2005 , vol. 16, # 11 p. 1897 - 1900
反应条件
1: With (R)-BINOL-SnCl4 in dichloromethane; toluene T=-78°C; enantioselective protonation; 1 h; 2: With hydrogenchloride in dichloromethane; toluene Hydrolysis; Further stages. Title compound not separated from byproducts.;
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
sodium hydroxide in water T=50°C; Methylation; 1 h;
参考文献
Dickman, Michael; Jones, J. Bryan
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 1957 - 1968
反应条件
sodium hydroxide in water T=45°C; 3 h; Title compound not separated from byproducts;
参考文献
Rose, Ulrich; Draeger, Martin
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2238 - 2243
反应条件
CSP 9803/5601; trifluoroacetic acid in di-isopropyl ether Resolution of racemate; Product distribution / selectivity;
参考文献
Duval, Raphael; Leveque, Hubert
Patent: US2004/260081 A1, 2004 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: 1.) cuprous iodide; 2.) diethylaluminum chloride / 1.) Et2O, -23 deg C, 1.5 h; 2.) Et2O, hexane, -78 deg C, 3 h then 0 deg C, 1 h 2: Ag2O / acetonitrile / Heating 3: LiAlH4 / tetrahydrofuran / 0 °C 4: periodic acid / RuCl3 View Scheme
参考文献
Wei, Han-Xun; Willis, Steven; Li, Guigen
Tetrahedron Letters, 1998 , vol. 39, # 45 p. 8203 - 8206