3,5-二氯-4-甲基苯甲酸合成路线 （共 13 条）
反应条件
aluminium trichloride in dichloromethane
参考文献
Rohm and Haas Company
Patent: US5304572 A1, 1994 ;
反应条件
1: 1,3-dichloro-5-iodo--2-methylbenzene With iso-propylmagnesium bromide in tetrahydrofuran T=-75°C; 0.75 h; 2: carbon dioxide in tetrahydrofuran
参考文献
Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario
European Journal of Organic Chemistry, 2006 , # 19 p. 4398 - 4404
反应条件
1: 2,6-dichlorotoluene With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-75°C; 0.75 h; 2: carbon dioxide in tetrahydrofuran; cyclohexane Title compound not separated from byproducts;
参考文献
Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario
European Journal of Organic Chemistry, 2006 , # 19 p. 4398 - 4404
反应条件
1.1: diisopropylamine / hexane; tetrahydrofuran / 2 h / -75 °C 1.2: 86 percent / tetrahydrofuran; hexane / Cooling 2.1: isopropylmagnesium bromide / tetrahydrofuran / 0.75 h / -75 °C 2.2: 92 percent / tetrahydrofuran View Scheme
参考文献
Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario
European Journal of Organic Chemistry, 2006 , # 19 p. 4398 - 4404
反应条件
1: AlCl3; chlorine View Scheme
参考文献
Pearson et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1412,1217
参考文献
Pearson et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1412,1217
反应条件
durch Austausch von NH2 gegen Cl;
参考文献
Claus; Beysen
Justus Liebigs Annalen der Chemie, 1891 , vol. 266, p. 223,227
反应条件
durch Austausch von NO2 gegen Cl;
参考文献
Claus; Boecher
Justus Liebigs Annalen der Chemie, 1891 , vol. 265, p. 361
反应条件
1: beim Nitrieren 2: durch Austausch von NO2 gegen Cl View Scheme
参考文献
Claus; Boecher
Justus Liebigs Annalen der Chemie, 1891 , vol. 265, p. 361
参考文献
Hinkel; Dippy
Journal of the Chemical Society, 1932 , p. 1468,1470
