2-碘-N,N-二甲基-4-吡啶胺合成路线 （共 3 条）
反应条件
1: With (2,2,6,6-tetramethylpiperidinyl)MgCl*LiCl in tetrahydrofuran
T=0°C; 1 h; Inert atmosphere;
2: With iodine in tetrahydrofuran
T=-30 - 25°C; Inert atmosphere;
参考文献
Jaric, Milica; Haag, Benjamin A.; Manolikakes, Sophia M.; Knochel, Paul
Organic Letters, 2011 , vol. 13, # 9 p. 2306 - 2309
反应条件
in N,N-dimethyl-formamide
T=120°C; 10.5 h; Microwave irradiation;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus
Patent: WO2013/107761 A1, 2013 ;
Location in patent: Page/Page column 53 ;
反应条件
1: sodium hydride; acetyl chloride / acetonitrile; mineral oil / |Reflux
2: N,N-dimethyl-formamide / 10.5 h / 120 °C / |Microwave irradiation
View Scheme
参考文献
Boehringer Ingelheim International GmbH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus
Patent: US2013/184248 A1, 2013 ;
