1-(2-羟基-4-甲氧基苯基)-2-(4-甲氧基苯基)乙酮合成路线 （共 27 条）
反应条件
1: N,N-dimethyl-formamide With phosphorus pentachloride T=55°C; Chlorination; 0.333333 h; 2: 2-hydroxy-4,4'-dimethoxy deoxybenzoin With boron trifluoride diethyl etherate in N,N-dimethyl-formamide T=20°C; Cycloaddition; 1 h;
参考文献
Balasubramanian, Sreenivasan; Nair, Muraleedharan G.
Synthetic Communications, 2000 , vol. 30, # 3 p. 469 - 484
反应条件
4-(N,N-dimethlyamino)pyridine T=100°C; 4 h;
参考文献
Li, Wanmei; Liu, Fangming; Zhang, Pengfei
Journal of Chemical Research, 2008 , # 12 p. 683 - 685
反应条件
1.1: BF3*Et2O; DMF 2.1: PCl5 / 0.33 h / 55 °C 2.2: 0.08 h / 30 °C 3.1: methanol / Acid hydrolysis View Scheme
参考文献
Narasimhachari et al.
Journal of Scientific and Industrial Research, 1953 , vol. 12 B, p. 287,291
参考文献
Anderson; Marrian
Journal of Biological Chemistry, 1939 , vol. 127, p. 649,652
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Mitsunobu reaction; 0.0833333 h;
参考文献
Kim, Young-Woo; Hackett, John C.; Brueggemeier, Robert W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4032 - 4040
反应条件
boron trifluoride diethyl etherate
T=85°C; Acylation; Friedel Crafts; 1.5 h;
参考文献
Balasubramanian, Sreenivasan; Nair, Muraleedharan G.
Synthetic Communications, 2000 , vol. 30, # 3 p. 469 - 484
反应条件
cerium(III) chloride; sodium iodide in acetonitrile
43 h; Heating;
参考文献
Kamada, Atsushi; Sasaki, Atsushi; Kitazawa, Noritaka; Okabe, Tadashi; Nara, Kazumasa; Hamaoka, Shinichi; Araki, Shin; Hagiwara, Hiroaki
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 1 p. 79 - 88
反应条件
1: 52 percent / AlCl3 / CH2Cl2 / 1 h / 20 °C
2: 94 percent / NaI; CeCl3*7H2O / acetonitrile / 43 h / Heating
View Scheme
参考文献
Kamada, Atsushi; Sasaki, Atsushi; Kitazawa, Noritaka; Okabe, Tadashi; Nara, Kazumasa; Hamaoka, Shinichi; Araki, Shin; Hagiwara, Hiroaki
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 1 p. 79 - 88
反应条件
1: 85 percent / BF3*OEt2 / 2 h / 100 °C
2: 81 percent / PPh3; DIAD / tetrahydrofuran / 0.08 h / 20 °C
View Scheme
参考文献
Kim, Young-Woo; Brueggemeier, Robert W
Tetrahedron Letters, 2002 , vol. 43, # 35 p. 6113 - 6115
反应条件
1: 85 percent / BF3*OEt2 / 2 h / 100 °C
2: 81 percent / PPh3; DIAD / tetrahydrofuran / 0.08 h / 20 °C
View Scheme
参考文献
Kim, Young-Woo; Brueggemeier, Robert W
Tetrahedron Letters, 2002 , vol. 43, # 35 p. 6113 - 6115
