2-(4-氯苯基)-2-氧代乙酸乙酯合成路线 （共 25 条）
反应条件
acetic acid in ethanol; water 2.5 h; Heating;
参考文献
Wyeth
Patent: US2008/125454 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
iodobenzene; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; water T=25 - 30°C;
参考文献
Ochiai, Masahito; Takeuchi, Yasunori; Katayama, Tomoko; Sueda, Takuya; Miyamoto, Kazunori
Journal of the American Chemical Society, 2005 , vol. 127, # 35 p. 12244 - 12245
反应条件
boron trifluoride diethyl etherate; dihydrogen peroxide; iodobenzene T=30°C; 7 h;
参考文献
Sheng, Jinmei; Li, Xiaolong; Tang, Mingfang; Gao, Botao; Huang, Guosheng
Synthesis, 2007 , # 8 p. 1165 - 1168
反应条件
1: With trifluorormethanesulfonic acid; Tl(Oac)3 T=60°C; 0.333333 h; 2: With water 0.166667 h; Further stages.;
参考文献
Lee; Jin; Choi
Chemical Communications, 2001 , # 11 p. 956 - 957
反应条件
lead(IV) acetate in tetrahydrofuran; dichloromethane T=-78 - -25°C; 2.5 h; 1) -78 degC, 1.5h 2) R.T., 1h;
参考文献
Moriarty, Robert M.; Penmasta, Raju; Prakash, Indra
Tetrahedron Letters, 1987 , vol. 28, # 8 p. 873 - 876
反应条件
anhydrous iron chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetylacetone in N,N-dimethyl-formamide T=125°C; 4 h;
参考文献
Zhao, Ming; Kuang, Chun Xiang; Cheng, Xue Zhi; Yang, Qing
Chinese Chemical Letters, 2011 , vol. 22, # 5 p. 571 - 574
反应条件
1: 1-chloro-4-iodobenzene With isopropylmagnesium chloride in tetrahydrofuran T=20 - 30°C; 1.16667 h; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 3: α-acetoxyacetyl chloride With copper(l) chloride in tetrahydrofuran T=30°C; Inert atmosphere;
参考文献
McLaughlin, Mark; Belyk, Kevin M.; Qian, Gang; Reamer, Robert A.; Chen, Cheng-Yi
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5144 - 5148
反应条件
silver(I) acetate in tetrahydrofuran T=50°C; 12 h; Inert atmosphereDarkness; SolventReagent/catalyst;
参考文献
Nolla-Saltiel, Roberto; Carrillo-Arcos, Ulises Alonso; Porcel, Susana
Synthesis (Germany), 2014 , vol. 46, # 2 p. 165 - 169
反应条件
1: AlCl3 / CH2Cl2 2: acetonitrile / 3 h / Heating View Scheme
参考文献
Kamal, Ahmed; Sandbhor, Mahendra; Ahmed, Kaleem; Adil; Shaik, Ahmad Ali
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3861 - 3866
反应条件
1: Et3N / dimethylformamide 2: Pb(OAc)4 / CH2Cl2; tetrahydrofuran / 2.5 h / -78 - -25 °C / 1) -78 degC, 1.5h 2) R.T., 1h View Scheme
参考文献
Moriarty, Robert M.; Penmasta, Raju; Prakash, Indra
Tetrahedron Letters, 1987 , vol. 28, # 8 p. 873 - 876
