2-甲氧基-4-甲基苯胺合成路线 （共 25 条）
反应条件
1: 76 percent / Cu(OAc)2 / CH2Cl2 / 2 h / 20 °C
2: 71 percent / DMF / Pd(OAc)2 / 0.02 h / microwave irradiation
View Scheme
参考文献
Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 91 - 98
反应条件
1: diluted aqueous H2SO4 / Diazotization.Erhitzen der Diazoniumsalz-Loesung mit KI auf dem Dampfbad
2: copper-powder / 275 °C
3: aqueous HI / 170 °C
4: aqueous hydrobromic acid; phosphorus / 320 °C
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参考文献
Sugii; Shindo
Yakugaku Zasshi, 1934 , vol. 54, p. 829,833
Chem. Zentralbl., 1935 , vol. 106, # I p. 698
反应条件
1.1: NaNO2; HCl / H2O / 1 h / 0 °C
1.2: 84 percent / KI / H2O / 12 h / 25 °C
2.1: 14 percent / Cu bronze / 5 h / 250 °C
3.1: 91 percent / BBr3 / CH2Cl2 / -78 - 25 °C
View Scheme
参考文献
Coleman; Guernon; Roland
Organic letters, 2000 , vol. 2, # 3 p. 277 - 280
反应条件
1: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating)
2: Py*HCl / 150 - 220 °C
3: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
1: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating)
2: Py*HCl / 150 - 220 °C
3: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
4: K2CO3 / ethanol
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
