2-氧代-3-甲基丁酸甲酯合成路线 （共 25 条）
反应条件
iodosylbenzene; tris(triphenylphosphine)ruthenium(II) chloride in dichloromethane 0.25 h; Ambient temperature;
参考文献
Mueller, Paul; Godoy, Jose
Tetrahedron Letters, 1982 , vol. 23, # 36 p. 3661 - 3664
反应条件
in diethyl ether T=0°C;
参考文献
Endo, Yasuyuki; Shudo, Koichi; Itai, Akiko; Hasegawa, Masashi; Sakai, Shin-ichiro
Tetrahedron, 1986 , vol. 42, # 21 p. 5905 - 5924
反应条件
hydrogenchloride in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
hydrogenchloride in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
2: 60 percent / iodosylbenzene / RuCl2(PPh3)3 / CH2Cl2 / 0.25 h / Ambient temperature View Scheme
参考文献
Mueller, Paul; Godoy, Jose
Tetrahedron Letters, 1982 , vol. 23, # 36 p. 3661 - 3664
反应条件
3-chloro-benzenecarboperoxoic acid
参考文献
Thorsett, E. D.
Tetrahedron Letters, 1982 , vol. 23, # 17 p. 1875 - 1876
反应条件
1: benzene / 72 h / Heating 2: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 3: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 4: sodium ethoxide / ethanol / 1 h / 40 °C 5: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Thorsett, E. D.
Tetrahedron Letters, 1982 , vol. 23, # 17 p. 1875 - 1876
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: 84 percent / triethylamine / 1 h / Ambient temperature 2: 95 percent / 1 M HCl / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
1: 92 percent / thionyl chloride, acetyl chloride / 4 h / Ambient temperature 2: 84 percent / triethylamine / 1 h / Ambient temperature 3: 95 percent / 1 M HCl / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
