4-(4-氯苯基)-4-羟基哌啶合成路线 （共 28 条）
反应条件
hydrogenchloride in ethyl acetate T=20°C;
参考文献
Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239
反应条件
sodium hydroxide; water
参考文献
Janssen et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1959 , vol. 1, p. 281,284
反应条件
N-benzyl-trimethylammonium hydroxide T=20°C; Neat (no solvent);
参考文献
Meshram; Reddy, B. Chennakesava; Goud, P. Ramesh
Synthetic Communications, 2009 , vol. 39, # 13 p. 2297 - 2303
反应条件
potassium carbonate in methanol; dichloromethane; N,N-dimethyl-formamide
参考文献
Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.
Patent: US2005/70549 A1, 2005 ;
反应条件
sodium carbonate; sodium iodide in acetonitrile Heating;
参考文献
Hulshof, Janneke W.; Casarosa, Paola; Menge, Wiro M. P. B.; Kuusisto, Leena M. S.; Van Der Goot, Henk; Smit, Martine J.; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2005 , vol. 48, # 20 p. 6461 - 6471
反应条件
1: 4-(4-chlorophenyl)-piperidin-4-ol With sodium carbonate; potassium iodide in 4-hydroxymethyl-1,3-dioxolane 0.25 h; 2: N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide in 4-hydroxymethyl-1,3-dioxolane T=60°C; 2 h; 3: With hydrogenchloride in 4-hydroxymethyl-1,3-dioxolane; isopropyl alcohol 0.333333 h;
参考文献
INSTITUT UNIVERSITARI DE CIENCIA I TECNOLOGIA
Patent: WO2008/80601 A2, 2008 ;
Location in patent: Page/Page column 10 ;
反应条件
potassium iodide; sodium carbonate in hydrogenchloride; isopropyl alcohol; acetone; toluene
参考文献
Adolor Corporation
Patent: US5798093 A1, 1998 ;
反应条件
hydrogenchloride; acetic acid 2 h; Heating;
参考文献
Yu; Caldera; McPhee; De Voss; Jones; Burlingame; Kuntz; Craik; Ortiz De Montellano
Journal of the American Chemical Society, 1996 , vol. 118, # 25 p. 5846 - 5856
反应条件
sodium azide; boron trifluoride diethyl etherate in 1,4-dioxane T=0°C;
参考文献
Harriman; Shao; Luly
Tetrahedron Letters, 2000 , vol. 41, # 46 p. 8853 - 8856
反应条件
1: With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 6 h; 2: With ammonium chloride in dichloromethane; water
参考文献
KINENTIA BIOSCIENCES LLC; FAIRFAX, David J.
Patent: WO2011/137331 A2, 2011 ;
Location in patent: Page/Page column 19-20 ;
WO 2011/137331 A2
