3,4-二羟基苯甲酸乙酯合成路线 （共 47 条）
反应条件
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 4: 84 percent / 12 h / 165 - 170 °C 5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C 6: pyridine / propan-2-ol View Scheme
参考文献
Knesl, Petr; Roeseling, Dirk; Jordis, Ulrich
Molecules, 2006 , vol. 11, # 4 p. 286 - 297
反应条件
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr View Scheme
参考文献
Molecules, , vol. 11, # 4 p. 286 - 297
反应条件
1: K2CO3 / butan-2-one / 84 h / Heating 2: KOH / ethanol / 2.5 h / Heating View Scheme
参考文献
Borisch, Konstanze; Diele, Siegmar; Goering, Petra; Kresse, Horst; Tschierske, Carsten
Journal of Materials Chemistry, 1998 , vol. 8, # 3 p. 529 - 543
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=0 - 20°C;
参考文献
Lin, Wenwei; Baron, Oliver; Knochel, Paul
Organic Letters, 2006 , vol. 8, # 24 p. 5673 - 5676
反应条件
potassium carbonate; potassium iodide in cyclohexanone
T=100°C; 18 h;
参考文献
Gardner, Richard Andrew; Belting, Mattias; Svensson, Katrin; Phanstiel IV, Otto
Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 308 - 318
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran; toluene
T=5 - 50°C; Mitsunobu reaction;
参考文献
Shirazi, Rahau S.; Ewert, Kai K.; Leal, Cecilia; Majzoub, Ramsey N.; Bouxsein, Nathan F.; Safinya, Cyrus R.
Biochimica et Biophysica Acta - Biomembranes, 2011 , vol. 1808, # 9 p. 2156 - 2166
反应条件
1.1: potassium carbonate / acetone / 0.5 h / 20 °C
1.2: 5 h / 50 °C
2.1: sodium hydroxide / water / 2 h / 70 °C
2.2: 1 h / 20 °C / pH 2 - 3
3.1: hydrogenchloride / 0.5 h / 20 °C
3.2: 14 h / 65 °C
3.3: 1 h / 20 °C
View Scheme
参考文献
Liu, Yajing; Zhang, Shulan; Li, Ye; Wang, Jianqiang; Song, Yu; Gong, Ping
Archiv der Pharmazie, 2012 , vol. 345, # 4 p. 287 - 293
